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Updated: Jan 16, 2026

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在口腔状细胞癌中NOTCH1信号通路的免疫组织化学评估:临床和预后意义

Juan Carlos de Vicente^1,2,3, Paloma Lequerica-Fernández^2,4, Héctor Torres Rivas⁵

¹Department of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias (HUCA), C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.

International journal of molecular sciences

|September 27, 2025

概括

NOTCH1通路表明口腔状细胞癌 (OSCC) 的预后不佳. 然而,联合p21和ps6表达可能会识别出具有良好的预后的患者,提供潜在的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
NOTCH1信号通路在各种癌症中起着复杂的作用.
了解OSCC的预后标志物对于患者管理至关重要.

研究的目的:

研究OSCC中NOTCH1通路的临床和预后意义.
为了评估NOTCH1的表达及其下游目标,HES1和p21.
探索与上皮细胞-介质细胞过渡 (EMT) 和mTORC1激活的潜在机械联系.

主要方法:

免疫组织化学用于评估165名OSCC患者样本中的NOTCH1,HES1和p21表达.
分析了临床病理学数据和生存结果.
研究了与EMT标记物 (E-cadherin,Vimentin) 和mTORC1激活 (-S6) 的关联.

主要成果:

在35%的瘤中发现NOTCH1表达,与晚期,转移和较短的疾病特异性生存期 (DSS) 相相关.
HES1和p21表达与早期临床阶段有关.
观察到p21和mTORC1激活 (pS6) 之间存在强烈的相关性,确定了预后良好的患者.

结论:

NOTCH1表达是OSCC中DSS差的独立预测器.
结合p21和ps6表达可能成为OSCC的有利预后分类器.
针对NOTCH1途径或利用p21/pS6可能为OSCC提供新的治疗策略.

关键词:

HES1 HES1 的时间在NOTCH1中,表皮介质介质的过渡.口腔状细胞癌的癌症.在p2121中,预后预后预后

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