乳菌发酵通过调节肠道微生物群和代谢物来抑制结肠炎的发展,以增强肠道屏障并降低炎症反应
Xiaoyan You1, Pengcheng Shi1, Wenjing Liu2
1Henan Engineering Research Center of Food Microbiology, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China.
International journal of molecular sciences
|September 27, 2025
概括
预防性使用 Lactobacillus fermentum S1,一种来自猫的益生菌,在小鼠模型中显著减少性结肠炎 (UC) 症状. 这种干预恢复了肠道微生物群的平衡,并增强了有益的代谢物,为UC预防提供了一种新的方法.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,治疗方法有限.
- 预防UC的预防策略是必不可少的,因为在管理既定疾病的挑战.
- 德克斯硫酸 (DSS) 诱导的大肠炎是一种广泛使用的模型,用于研究UC病变和测试干预措施.
研究的目的:
- 研究从猫体中分离出来的Lactobacillus fermentum S1作为DSS诱导的UC的预防性干预的潜力.
- 在UC模型中评估L. fermentum S1对生理学,微生物学和代谢学参数的影响.
主要方法:
- 在DSS诱导的UC小鼠模型中,用L. fermentum S1作为预防补充剂.
- 评估生理参数,包括体重和结肠长度.
- 分析肠道屏障功能,炎症标志物,肠道微生物群组成和便代谢物概况.
主要成果:
- 预防性L. fermentum S1补充剂显著改善了DSS诱导的体重减轻,结肠缩短和肠道屏障功能障碍.
- L. fermentum S1调节了肠道微生物群,增加了有益的属 (Akkermansia,Ligilactobacillus,Turicibacter,Prevotella_9) 和减少了致病性种类 (Parabacteroides,Acinetobacter).
- 补充增加了短链脂肪酸和抗炎代谢物hecogenin,在微生物和代谢物概况之间有很强的相关性.
结论:
- 乳酸菌发酵S1在预防和减轻性结肠炎症状方面显示出显著的潜力.
- 益生菌调节肠道微生物群,增强有益代谢物的产生,有助于其治疗作用.
- L. fermentum S1 是一种新的饮食补充剂的有希望的候选者,用于UC预防,并得到了对微生物群-代谢物相互作用的机械洞察的支持.
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