血糖危险指数 (GRI) 作为1型糖尿病中亚临床内皮功能障碍的生物标志物:一项跨部门研究
Nicole Di Martino1, Silvia Angelino1,2,3, Antonietta Maio1
1Unit of Endocrinology and Metabolic Diseases, University Hospital Luigi Vanvitelli, 80138 Naples, Italy.
International journal of molecular sciences
|September 27, 2025
概括
在1型糖尿病 (T1D) 中,较高的血糖危险指数 (GRI) 与减少的内皮前体细胞 (EPC) 相相关. 这表明GRI可能表明T1D患者的心血管风险.
科学领域:
- 内分泌学 在内分泌学.
- 心血管研究研究心血管研究
- 糖尿病管理 糖尿病管理
背景情况:
- 内皮原生细胞 (EPC) 对于保持血管健康至关重要.
- 降低EPC水平在1型糖尿病 (T1D) 中很常见,并且与内皮功能障碍有关.
- 血糖危险指数 (GRI) 衡量血糖控制质量,包括高血糖和低血糖风险.
研究的目的:
- 研究T1D成年人血糖危险指数 (GRI) 和循环EPC水平之间的关系.
- 确定GRI是否可以作为T1D中心血管风险的生物标志物.
主要方法:
- 一项涉及132名患有T1D的成年人进行密集胰岛素治疗的横截面研究.
- 使用14天的连续血糖监测数据计算了GRI.
- 通过流细胞计量量化EPCs (CD34+,CD133+,KDR+,CD34+KDR+) 的数量.
主要成果:
- 较高的GRI得分与较差的代谢健康指标有关.
- 具有较高GRI的参与者具有显著较低的CD34+,CD133+,KDR+和CD34+KDR+细胞数量.
- 在GRI和CD34+,CD34+CD133+,CD34+KDR+细胞计数之间观察到负相关性.
- 在HbA1c和EPC表型之间没有发现显著的联系.
结论:
- 患有T1D和高GRI水平的成年人表现出减少的EPC计数.
- GRI与特定的EPC表型有显著的关联,表明其作为T1D心血管风险生物标志物的潜力.
- GRI可能比单独的HbA1c更全面地评估与糖尿病有关的心血管风险.
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