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具有长期抗瘤作用的新型有机矿物复合体

Olga Ilinskaya¹, Galina Yakovleva¹, Pavel Zelenikhin¹

¹Microbiology Department, Institute of Fundamental Medicine and Biology of Kazan (Volga-Region) Federal University, Kazan Federal University, Kremlevskaya St., 18, Kazan 420008, Russia.

International journal of molecular sciences

|September 27, 2025

概括

研究人员开发了一种新的药物递送系统,使用反瘤酶binase,将其固定在岩石载体上,以便在胃肠道中持续释放. 这种方法增强了癌细胞的向性,并为长效抗瘤治疗提供了潜力.

科学领域:

生物技术是生物技术.
材料科学材料科学材料科学
在瘤学瘤学.

背景情况:

癌细胞的增殖通常是通过阻断MAPK通路来准的.
耐药性和KRAS突变限制了当前癌症疗法的有效性.
来自Bacillus pumilus的核糖核酶二酶与EGFR和RAS相互作用,抑制了这种途径.

研究的目的:

设计,优化和描述一种用于长期释放抗瘤双酶的新型复合物.
在含有克林诺皮托利特的微粒状岩石上固定双酶,以持续的胃肠道释放.
评估开发的复合体的抗瘤和解毒特性.

主要方法:

使用电子显微镜 (TEM,SEM) 和计算机断层扫描对克林诺皮托利特载体的表征.
通过原子力显微镜测量二相粒子大小.
使用热量计和胃肠道液体模型评估双酶稳定性和活性.

主要成果:

分析了载体的颗粒度,多孔度和元素组成.
双相粒子 (7nm) 有效地穿透了载体的毛孔.
比纳斯在高温下表现出稳定性,并在模拟的胃肠道液体中保持活性.
该复合物在20小时内呈现逐渐的酶释放,显示对腺癌细胞的细胞毒性.

结论:

成功创建了一种在clinoptilolite上固定的抗瘤双酶的新型长效复合体.
该复合体显示持续释放和强大的细胞毒性对癌细胞.
该系统为长期抗瘤和排毒疗法提供了一个有希望的方法.

关键词:

它具有抗瘤活性.这里是BinaseBinaseBinase 细胞毒性细胞毒性人类腺癌细胞.多孔性多孔性延长酶释放的时间.稳定的稳定性稳定的稳定性泽奥利特石是一种热带石.

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