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相关概念视频

ABC Transporters: Importer01:27

ABC Transporters: Importer

3.4K
ATP-binding cassette or ABC transporters are a class of ATP-driven pumps that hydrolyze ATP to move solutes across the membrane. They can be grouped into importers and exporters. While exporters are present in all domains of life, importers exist only in bacteria and some plants.
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
3.4K
ABC Transporters: Exporter01:31

ABC Transporters: Exporter

6.3K
ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...
6.3K
The ADP/ATP Carrier Protein01:42

The ADP/ATP Carrier Protein

4.1K
ADP/ATP carrier or AAC protein is the most abundant carrier protein in the inner mitochondrial membrane. It transports large quantities of ADP and ATP, equivalent to the average human body weight, every day. Among other transporters, ACC protein is one of the best-studied members of the mitochondrial carrier protein family. The ADP/ATP carrier protein comprises two transmembrane helices connected to a loop and a single alpha-helix on the matrix side. It switches between two conformational...
4.1K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.3K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.3K
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

278
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
278
Carrier-Mediated Transport01:06

Carrier-Mediated Transport

1.2K
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
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相关实验视频

Updated: Jan 16, 2026

Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
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Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1

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在人类生理学中,ABCC5/MRP5功能的新兴范式.

Jenai Chinoy1,2, Charlotte Meller2,3,4, Heidi de Wet2

  • 1Bedford Hospital South Wing, Kempston Road, Bedford MK42 9DJ, UK.

International journal of molecular sciences
|September 27, 2025
PubMed
概括

结合ATP的磁带输送器ABCC5输出循环核酸和谷氨酸合物,影响发育,新陈代谢和神经生物学. 在考虑ABCC5用于癌症治疗时,其多样化的生理作用需要谨慎.

关键词:
在ABC-运输商.ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5ABCC5C5C在Abcc5−/−小鼠中.在MRP5中,MRP5是MRP5.在NAAGAG中,我们在CAMP中,我们可以使用cAMP.cGMP的良好使用情况.cMOATAT 在全球范围内哈姆,哈姆,哈姆,哈姆,哈姆,哈姆,哈姆,哈姆.

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Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
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Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
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Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
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Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
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科学领域:

  • 生物化学 生化学
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • ATP结合盒 (ABC) 载体的C子家族包括具有多种功能的蛋白质,但包括ABCC5在内的几种蛋白质仍然是孤儿载体,其作用不明.
  • 虽然ABCC5与癌症的多药耐药性有关,但其更广泛的生理功能越来越被认可.

研究的目的:

  • 审查人类ABCC5的新兴理解,重点关注其生理作用,基板和超越癌症治疗的含义.
  • 突出ABCC5内源基质运输的重要性及其参与各种生物过程的重要性.

主要方法:

  • 对ABCC5研究的文献综述,包括使用淘汰模型 (小鼠,斑马鱼,海) 和结构分析的研究.
  • 分析与ABCC5的基质特异性相关的发现,包括循环核酸,谷氨酸合物和血液.

主要成果:

  • ABCC5输出内源基质,如cAMP,cGMP,NAAG和海姆,影响肠道形成,大脑功能,眼睛发育和铁代谢.
  • 在小鼠中,ABCC5删除会影响脂肪组织,胰岛素敏感性和神经行为,这表明它在谷氨酸信号传递和昼夜调节中的作用.
  • 结构研究揭示了ABCC5中的自身抑制机制,为抑制剂的发展提供了潜在的潜力.

结论:

  • ABCC5在发育,新陈代谢,神经生物学和男性生育能力方面发挥着重要的生理作用,超出了癌症多药性耐药性方面的已知功能.
  • 针对癌症治疗的ABCC5需要谨慎,因为它的关键功能被低估了,特别是在大脑和男性生殖系统.
  • 对ABCC5的基质特异性,调节和与ABCC12的相互作用进行进一步的研究对于开发有效的治疗策略至关重要.