在秘鲁的牛和猪中,ESBL-Escherichia coli的高发病率不明原因
Marília Salgado-Caxito1, Daphne Léon1,2, Olga Bardales3
1UMR MIVEGEC, IRD, CNRS, University of Montpellier, 34394 Montpellier, France.
Antibiotics (Basel, Switzerland)
|September 27, 2025
概括
扩展光谱β-乳糖酶产生的大肠杆菌 (ESBL-E. coli) 在秘鲁牲畜中很常见. 这项研究发现,患病率与特定物种因素有关,而不是农民的社会经济地位或抗生素使用,突出了未知的驱动因素.
科学领域:
- 兽医微生物学 兽医微生物学
- 抗微生物耐药性 抗微生物耐药性
- 一个健康,一个健康.
背景情况:
- 产生扩展谱β-乳糖酶的细菌大肠杆菌 (ESBL-E. coli) 在全球牲畜中普遍存在,特别是在低收入和中等收入国家.
- 了解ESBL-E. coli在牲畜中循环的驱动因素对于公共卫生至关重要,但仍然在很大程度上是未知的.
- 秘鲁的小规模农场显示了ESBL-E. coli便携在牲畜中的高患病率,需要进一步调查.
研究的目的:
- 为了比较ESBL-E. coli大肠杆菌在乳牛,猪和家禽中的便传播的流行情况,在秘鲁的利马和伊卡地区进行了比较.
- 确定与观察到ESBL-E. coli的流行相关的农场级驱动因素.
- 探索ESBL-E. coli患病率与农民社会经济地位,畜牧业实践和抗生素使用之间的关系.
主要方法:
- 在60个农场进行的横截面研究中,比较了乳牛 (N=244),猪 (N=261) 和母 (N=255) 中ESBL-E. coli便携的流行率.
- 管理农民调查问卷,涵盖社会经济地位,畜牧业,动物健康和抗生素使用.
- 使用Poisson通用线性模型进行统计分析,采用两种可变选择方法来识别相关驱动因素.
主要成果:
- 在98.3%的采样农场中检测到ESBL-E. coli.
- 利马的奶牛 (75%) 和猪 (61%) 患病率较高,而伊卡的母 (34%) 患病率较高.
- 较低的ESBL-E. coli患病率与养母的农场有关,农民管理畜牧业和医疗保健,以及更少的胃肠道疫情.
结论:
- 这项研究表明,独立于社会经济因素和报告的抗生素使用,物种特定的驱动因素主要负责ESBL-E. coli在秘鲁牲畜中广泛传播.
- 调查结果表明,除了抗生素使用和农民人口统计之外的因素显著影响ESBL-E. coli的流行.
- 建议进行进一步的研究,以阐明促进秘鲁牛和猪中高ESBL-E. coli流行的特定驱动因素.
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