压力下的怀孕:氧化压力作为孕产妇疾病的共同线索
Alexandru-Dan Assani1, Lidia Boldeanu2, Isabela Siloși3
1Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Life (Basel, Switzerland)
|September 27, 2025
概括
氧化压力有助于妊娠并发症,如先兆子和胎儿生长限制. 虽然抗氧化剂是有前途的,但它们的临床影响是不同的,需要个性化策略来改善孕产妇和胎儿的健康.
科学领域:
- 生殖生物学 生殖生物学
- 生物化学 生化学
- 病理生理学 病理生理学
背景情况:
- 氧化应激,反应性氧物种 (ROS) 和抗氧化防御之间的不平衡,与怀孕并发症有关.
- 虽然适度的ROS有助于胎盘功能,但过度的ROS会导致细胞损伤并损害胎盘健康.
- 与氧化压力相关的关键妊娠并发症包括先兆子 (PE),妊娠期糖尿病 (GDM),胎儿生长限制 (FGR) 和重复性怀孕丧失 (RPL).
研究的目的:
- 审查当前证据,将氧化应激与不良妊娠结果联系起来.
- 为了突出怀孕期间氧化应激的已确定的生物标志物.
- 评估抗氧化疗法在改善孕产妇和胎儿健康方面的有效性.
主要方法:
- 文献综述综合了当前关于氧化应激和怀孕并发症的研究.
- 识别和讨论关键的氧化应激生物标志物,包括马隆迪阿尔海德 (MDA),8-基-2'-脱氧氨酸 (8-OHdG) 和8-异质前列腺素F2α (8-异质PGF2α).
- 分析抗氧化剂干预措施的有效性,如维生素C和E,和叶酸.
主要成果:
- 氧化应激显著导致重大妊娠并发症的发病.
- 像MDA,8-OHdG和8-iso-PGF2α这样的生物标志物表明怀孕期间的氧化损伤.
- 抗氧化剂疗法显示出降低氧化标记物的潜力,但产生不一致的临床结果.
结论:
- 标准化生物标志物协议和个性化治疗策略对于有效的管理至关重要.
- 需要进一步的研究来优化抗氧化剂干预措施,以改善孕产妇和胎儿的健康结果.
- 解决个体遗传倾向和基线氧化状态是未来治疗方法的关键.
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