周围神经的原发性淋巴瘤:罕见或被误诊? 一个系统的审查
Ludovico Caruso1,2, Adriano Cannella1,2,3,4, Giulia Maria Sassara1,2,4
1Department of Ageing, Neurosciences, Head-Neck and Orthopaedics Sciences, Hand Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, 00168 Rome, Italy.
Life (Basel, Switzerland)
|September 27, 2025
概括
周围神经的原发性淋巴瘤 (PLPN) 是一种罕见的疾病,经常被误诊. 本综述强调了关键特征,并建议改善诊断和治疗是必要的,以获得更好的结果在PLPN.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 周围神经的原发性淋巴瘤 (PLPN) 是一种罕见的外节性非霍奇金淋巴瘤.
- 它经常模仿良性神经疾病,导致诊断延迟.
研究的目的:
- 系统地审查PLPN的临床,放射和病理特征.
- 评估PLPN的诊断和治疗策略.
主要方法:
- 在PubMed,Scopus和Web of Science中进行系统的文献搜索.
- 来自23项报告27例PLPN病例的研究数据的定性综合.
主要成果:
- 坐骨神经最常受到影响;诊断时的中位数年龄为58.
- 常见的症状包括运动缺陷,感官障碍和疼痛.
- B细胞淋巴瘤,特别是扩散的大型B细胞淋巴瘤,占主导地位. 核磁共振是非特定的,但DWI显示潜在的. 组合疗法是最常见的,两年生存率为83.3%.
结论:
- 这种PLPN很少见,而且可能被诊断不足.
- 早期识别需要多学科的合作和先进的成像.
- 需要进一步的研究来确定分子特征,诊断标准和治疗优化.
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