相关实验视频

Updated: Jan 16, 2026

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip

Published on: February 16, 2024

阴道微生物组及其与辅助生殖的关系:系统性审查和元分析

Marise Samama^1,2, Joji Ueno^2,3, Eduardo Carvalho de Arruda Veiga^2,3

¹Department of Gynecoloy, Escola Paulista de Medicina, Federal University of São Paulo-UNIFESP, São Paulo 04024-002, Brazil.

Life (Basel, Switzerland)

|September 27, 2025

概括

良好的阴道微生物群,特别是丰富的乳酸菌,显著改善了接受辅助生殖技术的妇女的怀孕和活产率. 这凸显了微生物组在繁殖成功中的关键作用.

科学领域:

生殖科学生殖科学
微生物组研究微生物组研究
临床产科和妇科临床产科和妇科

背景情况:

阴道微生物组组成是接受辅助生殖技术 (ART) 的女性生殖结果的关键决定因素.
了解阴道微生物群与ART成功之间的联系对于改善生育治疗至关重要.

研究的目的:

系统地审查和分析证据,证实有利的阴道微生物组与不利的微生物组相比,与优越的生殖结果有关.
确定与成功怀孕相关的特定微生物特征,例如乳酸菌的丰富性.

主要方法:

在PubMed和MEDLINE中使用"阴道微生物组"和"繁殖"等关键词,对过去10年内发表的研究进行系统审查和元分析.
包括1735个记录,将参与者分为有利和不利的阴道微生物组组.
用多变量关联与线性模型 (MaAsLin2) 来进行物种级分类学分辨率的56名女性队列的生物信息分析.

主要成果:

与阴道微生物组不利的女性相比,具有良好的阴道微生物组的女性的怀孕率 (RR: 1.59) 和活产率 (RR: 1.41) 显著更高.
在具有有利微生物组的妇女中观察到明显较低的流产率 (RR:0.65).
生物信息分析显示,高相对丰富的Lactobacillus crispatus与怀孕的可能性增加六倍有关.

结论:

一个有利的阴道微生物组,以高丰富的Lactobacillus crispatus为特征,与改善的生殖结果密切相关,包括更高的临床怀孕和活产率.
这些发现强调了阴道微生物组在ART成功中的重要性,并建议治疗干预的潜在目标.
尽管有积极的关联,但分析指出,所包含的研究中存在低质量的偏差,这需要谨慎的解释.

关键词:

临床怀孕率临床怀孕率活生生的出生率是多少怀孕期间的损失怀孕期间的损失系统性审查系统性审查阴道的微生物组

更多相关视频

Models of Murine Vaginal Colonization by Anaerobically Grown Bacteria

Models of Murine Vaginal Colonization by Anaerobically Grown Bacteria

Published on: May 25, 2022

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

相关概念视频

Infertility in Females

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...

Vagina

Vagina

The vaginal canal is a tubular structure averaging about 10 cm in length that acts as the entryway to the female reproductive system and the passageway for menstrual flow and childbirth. The interior walls of the vagina exhibit concentric folds called rugae and are topped by an area known as the fornix, which connects with the protruding cervical portion of the uterus. This canal is comprised of an external fibrous layer, a muscular middle layer, and an inner lining with mucosal rugae, which...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...