小儿过敏疾病中的微生态-免疫轴:失衡机制和监管干预
Ziyi Jiang1, Jie Zhu1, Zhicheng Shen1
1Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China.
Nutrients
|September 27, 2025
概括
儿童过敏性疾病正在增加,与肠道微生物组失衡有关. 皮肤-肺-肠轴起着关键作用,向微生物群为免疫耐受性提供了有希望的干预措施.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 儿科过敏症儿童过敏症
背景情况:
- 全球儿科过敏性疾病的增加,如阿托皮性皮肤炎,过敏性鼻炎和喘.
- 微生物群-免疫轴失调是过敏状况的关键驱动因素.
- 皮肤-肺-肠轴促进多器官免疫通信.
研究的目的:
- 审查生命早期微生物群的发展及其与过敏性疾病的联系.
- 探索皮肤-肺-肠轴在免疫耐受性中的作用.
- 总结当前针对过敏疾病的针对微生物群的干预措施.
主要方法:
- 对微生物群,免疫系统和过敏性疾病研究的文献综述.
- 皮肤-肺-肠轴在免疫恒温和失生症中的分析.
- 治疗策略的概述,包括益生菌,益生菌,共生菌,后生菌和FMT.
主要成果:
- 微生物失调,减少多样性和不平衡的比例有助于免疫失调.
- 皮肤-肺-肠轴对于维持先天性和适应性免疫是至关重要的.
- 早期的微生物殖民对于免疫成熟至关重要;干扰与过敏有关.
结论:
- 皮肤-肺-肠轴充当与婴儿过敏相关的跨器官调节网络.
- 针对微生物群的干预措施显示出调节宿主免疫力的潜力.
- 这一综述为个性化预防和治疗过敏疾病提供了基础.
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