便短链脂肪酸可预测糖尿病前期和2型糖尿病风险:一项探索性横截面研究
Rocío Puig1,2,3, Marina Idalia Rojo-López2,4, Josep Julve2,5
1Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
Nutrients
|September 27, 2025
概括
便酸水平与降低2型糖尿病风险,但增加糖尿病前期风险有关. 需要进一步的研究来了解这些短链脂肪酸发现的生物学意义.
科学领域:
- 代谢学 代谢学 代谢学
- 微生物组研究的研究.
- 糖尿病是一种糖尿病.
背景情况:
- 在糖尿病前期 (preDM) 和2型糖尿病 (T2D) 等失糖状态下,肠道微生物群的组成会发生变化.
- 短链脂肪酸 (SCFA) 是微生物代谢物,可能反映这些变化,但它们对血糖状况的预测值尚不清楚.
研究的目的:
- 在地中海成年人群中,研究便中SCFA度与血糖状况 (正常血糖,糖尿病前期,2型糖尿病) 之间的关联.
- 评估SCFA在糖尿病前期和2型糖尿病风险方面的预测作用.
主要方法:
- 对Di@bet.es研究中的88名参与者的分析,分为正常血糖 (非DM),糖尿病前期 (preDM) 和2型糖尿病 (T2D) 组.
- 通过大规模测序和使用气相色谱-质谱学的SCFA量化进行肠道微生物群分析.
- 调整了多重后勤回归模型以确定SCFA和代谢状态之间的关联.
主要成果:
- 与非DM和DM前组相比,T2D参与者的便酸显著降低.
- 较低的便酸与降低T2D风险 (OR=0.561) 相关,当前DM是参考时.
- 更高的酸预测了增加的前DM风险 (OR=1.422),而酸与前DM相反相关 (OR=0.714).
结论:
- 便酸水平显示出双重关联:降低T2D风险,但增加糖尿病前期风险.
- 这些SCFA与血糖状况相关的确切生物学机制需要进一步研究.
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