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超加工食品消费和系统性炎症生物标志物:一个范围审查

Jacopo Ciaffi^1,2, Luana Mancarella¹, Claudio Ripamonti¹

¹Medicine & Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.

|September 27, 2025

概括

超加工食品的消费与较高的C-反应蛋白 (CRP/hs-CRP) 相关,这是一种关键的炎症生物标志物,在成人和一些儿童中. 其他炎症标志物与超加工食品存在不一致的关联.

科学领域:

营养科学营养科学
生物标志物生物标志物
慢性疾病流行病学慢性疾病流行病学

背景情况:

超加工食品 (UPF) 消费是一个全球趋势,与慢性疾病和炎症失调有潜在的联系.
了解UPF摄入量和全身炎症之间的关系对于公共卫生至关重要.

研究的目的:

进行范围审查,绘制UPF消费和系统性炎症生物标志物的人类证据.
单独对儿科和成人群体进行综合发现.

主要方法:

一个全面的搜索策略将UPF的术语与特定的炎症生物标志物 (例如CRP/hs-CRP,IL-6,TNF-α) 结合在一起.
包括的研究评估了与UPF摄入量相关的循环炎症标志物.
对不同年龄组的数据进行了合成和分析:儿童/青少年和成年人.

主要成果:

包括24项研究,评估各种炎症生物标志物.
在儿童/青少年中,更高的UPF摄入量与大型队列和早产婴儿中CRP/hs-CRP升高有关.
在成年人中,增加的UPF消耗经常与更高的CRP/hs-CRP,IL-6和TNF-α水平有关,尽管其他生物标志物显示出不一致的模式.

结论:

高水平的全身炎症生物标志物,特别是CRP/hs-CRP,经常与成人和一些儿科组的高UPF消耗有关.
虽然IL-6和TNF-α在特定人群中表现出相关性,但IL-1β,MCP-1,PAI-1和叶黄素与UPF摄入量呈现出不一致的关系.
这些发现突显了UPF和关键炎症标志物之间的一致联系,需要进一步研究机制和健康影响.

关键词:

在C-反应性蛋白质中.生物标志物生物标志物食物食物食物食物这是一种炎症炎症炎症炎症.它们包括interleukins和interleukins.超级加工的超级加工

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