绝经后代谢失调:对膝关节健康的影响
Ivana Minaković1,2, Jelena Zvekić-Svorcan1,3, Mirjana Smuđa1,4
1Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.
Journal of clinical medicine
|September 27, 2025
概括
代谢综合征与患有膝关节关节炎的绝经后妇女膝关节损伤和功能恶化有关. 治疗代谢综合征可能会改善这些患者的治疗结果.
科学领域:
- 整形外科 整形外科 整形外科
- 代谢医学是一种代谢医学.
- 老年学是一门学科.
背景情况:
- 骨关节炎 (OA) 是一种退行性关节疾病,其特征是软骨的分解和炎症.
- 代谢因素越来越多地被认为对OA发展和进展起着作用.
研究的目的:
- 为了研究代谢综合征和膝盖损伤之间的关联,在绝经后患有膝关节骨关节炎的女性.
- 评估代谢综合征作为膝关节OA严重程度和功能衰退的潜在可修改风险因素.
主要方法:
- 观察性横截面研究,涉及200名绝经后妇女 (60-75岁) 患有膝盖疼痛.
- 病例组 (n=120) 已验证了膝关节关节炎 (凯尔格伦-劳伦斯II-IV级);对照组 (n=80) 没有放射性变化.
- 收集了临床,人体测量和代谢数据;使用下肢功能尺度和莱克斯内指数评估功能状态.
主要成果:
- 代谢综合征与放射性膝关节损伤显著相关 (效果大小为4.7%),并且在调整吸烟和体力活动后仍然显著.
- 与没有代谢综合征的人相比,患有膝关节骨质炎和代谢综合征的参与者表现出较差的功能膝关节状况 (p < 0.05).
- 在两组之间观察到代谢综合征患病率,透气血压和禁食葡萄糖水平的显著差异.
结论:
- 代谢综合征是膝关节骨关节炎的绝经后妇女放射性膝关节损伤的独立危险因素.
- 代谢综合征导致这种患者群体的功能结果更差.
- 准代谢综合征是治疗膝关节关节炎和改善患者功能的一种潜在策略.
相关概念视频
Bone Disorders
5.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.1K
Menopause
3.5K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
3.5K
Cholesterol: Significance and Regulation
1.2K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.2K
Regulation of Metabolism
11.4K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.4K
Overview of Lipid Metabolism
4.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.8K
Bone Remodeling
40.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.3K


