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[¹⁸F]FDG PET/CT对鼻癌中新辅助化学放射治疗反应的预测值

Natale Quartuccio¹, Federico Sireci², Sabina Pulizzi¹

¹Nuclear Medicine Unit, Ospedali Riuniti Villa Sofia-Cervello, 90146 Palermo, Italy.

Journal of clinical medicine

|September 27, 2025

概括

基线[18F]FDG PET/CT代谢参数如SUVmax和MTV可以预测鼻癌 (NPC) 中的新辅助化疗 (NAC) 反应. 较低的基线SUVmax和MTV表明更好的NAC反应,有助于NPC个性化治疗策略.

科学领域:

在瘤学瘤学.
核医学就是核医学.
放射学放射学是一门学科.

背景情况:

鼻癌 (NPC) 是一种与爱斯坦-巴尔病毒 (EBV) 密切相关的头恶性瘤.
新辅助化学疗法 (NAC) 随后的化学放射疗法改善了局部发达NPC的结果,但反应各不相同.
预测NAC反应对于定制治疗策略至关重要.

研究的目的:

评估基线[18F]FDG PET/CT参数是否可以预测局部发达NPC患者的NAC反应.
为了确定NAC反应分层的早期代谢生物标志物.

主要方法:

在NAC之前,对27名局部发达NPC患者进行了回顾性分析,这些患者接受了基线[18F]FDG PET/CT.
从初级瘤中提取的定量PET参数 (SUVmax,SUVmean,MTV,TLG).
通过RECIST 1.1评估NAC反应;使用t测试和ROC分析比较响应者与非响应者.

主要成果:

70.4%的患者对NAC有反应.
与非响应者相比,受试者在基线SUVmax (p=0.021),MTV (p=0.045) 和TLG (p=0.038) 显著较低.
经过ROC分析,SUVmax>12.5和MTV>20.0 cm3被认为是NAC反应不佳的值.

结论:

基线[18F]FDG PET/CT代谢参数,特别是SUVmax和MTV,可以帮助NPC中的NAC反应分层.
这些生物标志物可能有助于治疗前分层,以实现个性化治疗方法.
需要进行更大规模的前性研究来证实这些发现,因为样本规模有限.

关键词:

这是一辆SUVmax,SUVmax.[18F]FDG PET PET 是一个很好的方法.代谢性瘤的体积和体积.鼻癌 (nasopharyngeal carcinoma) 是一种发生在鼻的癌症.新辅助性化疗或放射治疗.总的损伤糖解.

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