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评估自动化血管压力器管理算法,使用低极限控制用于手术内低血压:一个模拟研究研究

Emi Morinushi¹, Osamu Nagata², Fumiyo Yasuma²

¹Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan.

Journal of clinical medicine

|September 27, 2025

概括

新的评估指标,包括低于值的时间比例 (PTBT) 和低于值的平均值 (MVBT),改善了用于预防手术内低血压的血管压力控制策略的评估.

科学领域:

麻醉学麻醉学
生物医学工程生物医学工程
药理学药理学是指药理学的学科.

背景情况:

术内低血压可能导致患者的不良后果.
有效的血管压力控制对于维持血液动力学稳定性至关重要.
当前的评估指标可能无法完全捕捉下限控制策略的细微差别.

研究的目的:

开发和评估用于评估下限血管压力控制的新型指标.
在模拟的低血压场景中比较不同的血管压缩剂剂量策略.
确定最佳指标,以预防长期的手术内低血压.

主要方法:

使用模拟软件开发了一种血压生成模型和一种自动化血管压缩剂管理模型.
模拟了四种血管压缩剂剂量策略:玻尿酸,重复低剂量玻尿酸和连续输液.
计算的评估指标:低于值的时间比例 (PTBT),低于值的平均值 (MVBT),平均缩血压 (sBP),中位数性能误差 (MDPE) 和中位数绝对性能误差 (MDAPE).

主要成果:

持续输液策略显著降低了低血压的持续时间和严重程度 (较低的PTBT和MVBT).
PTBT和MVBT有效量化了低血压和sBP超过值的程度.
在没有固定目标的情况下,MDPE和MDAPE显示出很高的可变性,并且不太适合评估下限控制.

结论:

PTBT,MVBT和平均sBP是评估血管压力控制稳定性和避免低血压的有价值指标.
当目标是超过一个值而不是实现一个特定目标时,MDPE和MDAPE对定量评估不太适合.
开发的指标提供了对下限血管压力控制策略的更全面评估.

关键词:

血压血压血压血压评估指标是评估指标.下限控制控制的下限控制模拟模拟是指一个模拟模拟.血管压缩器是一种压缩器.

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