在关节疾病中进行自身注射:系统性审查
Sylwia Orzeszek1, Andrzej Malysa1, Andrej Jenca2
1Department of Experimental Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland.
Journal of clinical medicine
|September 27, 2025
概括
自生注射,特别是富血小板血 (PRP),显示出治疗关节疾病 (TMD) 的希望. 这些微创疗法有效地减少了TMD患者的疼痛,并改善了功能.
科学领域:
- 整形外科 整形外科 整形外科
- 再生医学是一种再生医学.
- 口腔和牙面部外科手术
背景情况:
- 关节疾病 (TMD) 涵盖了影响关节和肌肉的各种肌肉骨疾病.
- 自生注射正在成为治疗TMD疼痛和功能障碍的最小侵入性治疗方法.
- 这些疗法在各种TMD类型中的有效性需要进一步研究.
研究的目的:
- 系统地审查自生注射治疗部疾病 (TMD) 的临床有效性.
- 评估治疗对TMD患者疼痛减轻和功能改善的影响.
主要方法:
- 从2015年1月到2025年5月,在主要数据库 (MEDLINE,Embase,Web of Science) 中进行了全面的文献搜索.
- 包括对TMD的关节内或肌肉内自身注射的研究.
- 使用Cochrane偏差风险2和JBI批判性评估工具评估研究质量.
主要成果:
- 13项研究 (6项RCT,7项非随机化) 符合标准,重点关注关节内疾病和肌肌关节疼痛.
- 富血小板血 (PRP) 是研究最多的药物,显示显著的疼痛减轻和改善下的移动性.
- 与氨酸,皮质类固醇和盐水相比,PRP通常显示出更好的结果,没有报告严重不良事件.
结论:
- 富血小板血 (PRP) 和富血小板纤维素 (PRF) 注射似乎有效缓解TMD疼痛并增强运动能力.
- 治疗方案和随访时间的变化限制了最终的结论,并阻止了元分析.
- 标准化随机对照试验对于在TMD管理中为自身注射疗法制定明确的临床指导方针至关重要.
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