成年患者食用腐蚀性物质的内镜结果和炎症标志物相关性
Seymur Aslanov1, Ali Senkaya1, Nalan Gulsen Unal1
1Department of Internal Medicine, Division of Gastroenterology, Ege University Faculty of Medicine, Izmir 35040, Turkey.
中性粒细胞与淋巴细胞的比率 (NLR) 和C反应蛋白 (CRP) 可以帮助预测因食用腐蚀性物质而导致的严重胃肠道损伤. 这些炎症标志物可能有助于在内镜无法使用时做出临床决定.
科学领域:
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 腐蚀性物质的摄入会导致严重的胃肠道损伤和发病率.
- 早期风险分层是至关重要的,但缺乏可靠的伤害严重性的非侵入性预测指标.
研究的目的:
- 评估成年食用腐蚀剂患者的临床特征.
- 调查炎症标志物与内镜损伤严重程度之间的相关性.
主要方法:
- 对83名成年患者进行了食道胃管腺镜 (EGD) 进行腐蚀性摄入的回顾性分析.
- 使用扎尔加分类 (轻度与重度) 的等级内镜损伤.
- 通过ROC分析评估了中性粒细胞与淋巴细胞比率 (NLR),C反应蛋白 (CRP) 和损伤严重程度之间的相关性.
主要成果:
- 严重的伤害与更长的住院时间,更高的并发症率和器官干扰相关 (p < 0.001).
- 在损伤严重程度和NLR (r = 0.357,p = 0.001) 和CRP (r = 0.247,p = 0.024) 之间发现了弱但显著的相关性.
- 2.95的NLR切断值 (AUC = 0.804) 和2.5的CRP切断值 (AUC = 0.706) 预测了严重的伤害.
结论:
- 早期内镜评估对于评估腐蚀性损伤至关重要.
- NLR和CRP显示出作为预测受伤严重程度的非侵入性指标的潜力.
- 这些标志物可能有助于临床决策,特别是当内镜有限时.
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