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在2型糖尿病中揭示亚临床右心室功能障碍:一个斑点跟踪心声图学研究

Laura-Cătălina Benchea^1,2, Larisa Anghel^1,2, Nicoleta Dubei¹

¹Internal Medicine Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700503 Iași, Romania.

Medicina (Kaunas, Lithuania)

|September 27, 2025

概括

2型糖尿病 (T2DM) 可以导致早期右心室 (RV) 缩功能障碍,即使常规心声图结果正常. 斑点追踪回声心脏学,测量RV全球纵向应变 (RV GLS) 和RV自由壁应变 (RVFWS),有效检测这种亚临床损伤.

科学领域:

心脏病学心脏病学
糖尿病学糖尿病学
医疗成像医学成像

背景情况:

2型糖尿病 (T2DM) 显著增加心血管疾病的风险.
糖尿病心肌病包括左心室功能障碍,但亚临床右心室 (RV) 功能障碍越来越被认可.
早期检测RV功能障碍对于T2DM患者心血管风险分层至关重要.

研究的目的:

确定斑点跟踪回声心脏学是否可以在T2DM患者中识别亚临床RV静脉缩功能障碍.
为了评估VR功能,尽管正常的常规心声学指数和保存的全球缩功能.
为了将RV菌株参数与血糖控制 (HbA1c) 相对应.

主要方法:

一项涉及36名T2DM患者和41名对照者的横截面研究.
综合性跨胸腔心声学,包括传统的RV参数 (TAPSE,TV S',RVFAC) 和斑点追踪衍生菌株 (RV GLS,RVFWS).
相关性和ROC曲线分析以评估关联和诊断性能.

主要成果:

传统的RV参数在各组之间是相似的.
糖尿病患者显示RV GLS显著减少 (-13.86 ± 6.07%对比 -18.59 ± 2.27%) 和RVFWS (-15.64 ± 4.30%对比 -19.03 ± 3.53%).
HbA1c与RV菌株损伤正相关;RV GLS和RVFWS是RV功能障碍的独立预测因素.

结论:

亚临床RV缩功能障碍在T2DM早期存在,通常不会被传统心声回声学检测出来.
斑点追踪回声心脏学,特别是RV GLS和RVFWS,提供了对心肌功能障碍的敏感检测.
这些发现凸显了斑点追踪回声心脏学在T2DM早期心血管风险评估中的有用性.

关键词:

早期心血管风险分层的分层.右心室功能障碍是什么斑点跟踪回声心脏图谱 (speckle-tracking echocardiography) 是一种跟踪斑点的回声心脏图谱.2型糖尿病是什么?

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