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炎症性肠病中的急性胰腺炎:来自欧洲潘多拉研究的结果
Maria Cristina Conti Bellocchi1, Martina Cattani Mottes1, Andreas Blesl2
1Department of Medicine, Diagnostic and Interventional Endoscopy of the Pancreas, The Pancreas Institute, University Hospital of Verona, 37134 Verona, Italy.
急性胰腺炎 (AP) 影响0.58%的炎症性肠病 (IBD) 患者,通常是轻微的. 阿扎西奥普林是主要原因,具有克罗恩病和性结肠炎的明显危险因素.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 与急性胰腺炎 (AP) 的风险增加有关.
- 关于IBD患者的AP患病率,原因和结果的数据有限.
研究的目的:
- 为了确定IBD患者中AP的患病率.
- 研究IBD中AP的病因,临床表现和结果.
主要方法:
- 在34个欧洲中心进行了10年 (2011-2020) 的回顾性分析.
- 两步分析:流行率调查,随后收集有关疾病特征,病因和结果的数据.
主要成果:
- 在IBD患者中AP的患病率为0.58% (398/68,989).
- 大多数AP病例在临床上是轻度 (86.9%) 和 edematous (62.8%).
- 阿扎西奥普林是主要的病因 (55.3%),其次是胆道病因 (14.8%) 和自身免疫病因 (7.8%). 克罗恩氏病患者具有独特的风险概况,而性结肠炎患者显示出更多的自身免疫/异常病因.
结论:
- 潘多拉研究发现IBD患者的AP患病率为0.58%,低于预期.
- 在IBD中AP通常在临床和放射学上是轻微的.
- 阿扎西奥普林是IBD患者中最常见的AP原因,特别是在治疗的早期. 对于CD和UC患者,存在不同的风险因素.
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