雷多克斯和炎症生物标志物与阻塞性睡眠呼吸暂停的存在和严重性之间的关联
Ana Ninić1, Branislava Rajkov1, Jelena Kotur-Stevuljević1
1Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.
Medicina (Kaunas, Lithuania)
|September 27, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 与增加的氧化应激和炎症有关. 研究表明,OSA的严重程度与较高的总氧化状态 (TOS) 和TGF-β1 mRNA以及较低的sRAGE水平相关.
科学领域:
- 生物医学研究生物医学研究
- 睡眠医学 睡眠医学
- 心血管健康 心血管健康
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一个日益严重的公共卫生问题,与严重的健康并发症有关.
- 内皮功能障碍,氧化应激和炎症是OSA病理生理学的关键因素.
- 了解将OSA与其并发症联系在一起的生物机制至关重要.
研究的目的:
- 在OSA患者中调查氧化还原状态,炎症和flRAGE和TGF-β1的基因表达之间的关系.
- 评估OSA的存在和严重程度如何与这些生物标志物相关.
主要方法:
- 分析了一组125名OSA患者和42名对照组.
- 测量了氧化还原和炎症标志物的血清和血水平.
- 在外周血液单核细胞中量化了flRAGE和TGF-β1mRNA的基因表达.
主要成果:
- 在OSA患者中,氧化应激和炎症增加 (TAS,CRP较高;sRAGE较低).
- OSA的严重程度与总氧化状态 (TOS) 和TGF-β1mRNA的增加相关,并减少了sRAGE.
- TOS与OSA严重程度独立相关.
结论:
- 在OSA患者中,氧化应激和炎症增加.
- 增加的OSA严重程度与TOS和TGF-β1mRNA的升高有关,并减少了sRAGE.
- 结合的氧化还原-炎症生物标志物概况与OSA的存在和严重程度有关.
关键词:
对于高级糖化最终产品的全长受体.阻塞性睡眠呼吸暂停症是什么氧化应激指数是指氧化应激指数.对于高级糖化最终产品的可溶性受体.总的抗氧化剂状态.总氧化状态 总氧化状态转化增长因子β1的转化增长因子β1更多相关视频
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