社会时差中的肠道微生物群轴:代谢功能障碍和慢性治疗创新的新框架
Christos Savvidis1, Viviana Maggio2, Manfredi Rizzo2
1Department of Endocrinology, Hippokration General Hospital, 11527 Athens, Greece.
Medicina (Kaunas, Lithuania)
|September 27, 2025
概括
社会时差会破坏肠道微生物群,导致代谢障碍. 针对这个昼夜微生物组轴的干预措施显示出预防和治疗诸如肥胖和2型糖尿病等疾病的前景.
科学领域:
- 时间生物学 时间生物学
- 微生物组研究 微生物组研究
- 代谢健康 代谢健康
背景情况:
- 社会时差,身体内部时钟和社会时间表之间的不匹配,与代谢疾病有关.
- 肠道微生物群在调解社会时差对宿主新陈代谢的影响方面发挥着至关重要的作用.
- 微生物群-肠道-代谢轴的破坏有助于胰岛素抵抗和全身炎症.
研究的目的:
- 审查与社会时差,肠道微生物群和代谢功能障碍相关的机制性见解和临床证据.
- 突出肠道微生物群作为治疗目标,以减轻昼夜干扰的代谢后果.
- 探索慢性治疗策略,以解决昼夜微生物组 misalignment 的问题.
主要方法:
- 关于社会时差对微生物节律性,SCFA产生和肠道屏障功能的影响的机制研究的综合.
- 对时间限制养,益生菌,黑激素和FMT等干预措施的临床前和临床证据的审查.
- 在昼夜干扰和代谢健康的背景下,对微生物群-肠道-代谢轴的分析.
主要成果:
- 社会时差扰乱微生物节奏,减少有益的短链脂肪酸 (SCFA) 生产,并损害肠道屏障功能.
- 这些干扰促进全身炎症,并导致胰岛素抵抗和代谢功能障碍.
- 针对肠道微生物群的干预措施可以恢复平衡,并重新调整宿主和微生物节奏.
结论:
- 肠道微生物群是社交时差的不利代谢影响的关键调解者.
- 针对昼夜微生物组轴的时间治疗策略为预防和治疗代谢疾病提供了一种新的方法.
- 解决昼夜微生物组错位是改善现代人群代谢健康的临床可行的途径.
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