对于韩国孕妇的完整血清参数的生理变化和三个月特定的参考间隔
Heejin So1, Kyungsuk Kwon2, Sukhyun Jung2
1Department of Laboratory Medicine, Gimpo Woori Hospital, Gimpo 10099, Republic of Korea.
Medicina (Kaunas, Lithuania)
|September 27, 2025
概括
这项研究为韩国孕妇的全血细胞计 (CBC) 参数建立了新的妊娠年龄特定的参考间隔. 这些发现有助于临床医生在怀孕期间准确解释CBC结果.
科学领域:
- 血液学 血液学 血液学
- 产科 产科 产科 产科 产科
- 临床化学 临床化学
背景情况:
- 怀孕会导致显著的生理和血液学变化.
- 现有的全血细胞计 (CBC) 参考间隔通常基于非孕妇人群.
- 这限制了怀孕期间CBC参数的临床实用性.
研究的目的:
- 在韩国妇女怀孕期间评估CBC参数的纵向变化.
- 为CBC参数建立妊娠年龄特定的参考间隔.
- 改善孕妇CBC结果的解释.
主要方法:
- 在怀孕期间和怀孕后的五个时间点对韩国妇女的CBC测试进行了回顾性分析.
- 包含来自孕妇门诊患者和非孕妇对照的CBC数据,以建立参考间隔.
- 使用自动化血液学分析仪测量CBC参数,并通过2.5和97.5百分位数建立参考间隔.
主要成果:
- 白血细胞 (WBC) 数量在第二个三个月显著增加.
- 血红蛋白 (Hgb) 水平在怀孕第二季度显著下降.
- 血小板 (PLT) 数量在整个怀孕期间显示出一致的,渐进的下降.
结论:
- 在韩国孕妇中,CBC参数的纵向变化是特征.
- 成功建立了WBC,Hgb和PLT的妊娠年龄特定参考间隔.
- 预计开发的参考间隔将提高怀孕期间CBC结果的临床解释.
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