系统性炎症和心肌再极化心力衰竭和阻塞性睡眠呼吸暂停中的异质性:对心律失常风险的影响
Emirhan Çakır1, Uğur Özkan1, İlker Yılmam2
1Department of Cardiology, School of Medicine, Trakya University, 22030 Edirne, Turkey.
Medicina (Kaunas, Lithuania)
|September 27, 2025
概括
系统性免疫炎症指数 (SII) 升高和阻塞性睡眠呼吸暂停综合征 (OSAS) 严重程度预测心力衰竭患者的心脏再极化问题. 这些生物标志物可以帮助分层风险和指导干预,以获得更好的心血管结果.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 炎症研究 炎症研究
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 和心力衰竭 (HF) 经常共存,通过炎症和自主功能障碍增加心血管风险.
- 研究系统性炎症 (SII) 和OSAS严重程度 (AHI) 与心肌复极化异质性在HF患者之间的联系至关重要.
研究的目的:
- 评估SII和AHI对心肌再极化异质性对HF和OSAS患者的影响.
- 在这个患者队列中确定复极异构和心室失常的预测因子.
主要方法:
- 160名高频患者的回顾性研究证实了OSAS (AHI ≥ 5).
- 通过QT分散 (QTd) 进行分层,并测量SII,AHI和心电图标记 (QTd,QRS-T角度,TPEI).
- 后勤回归和ROC分析以确定异质性和心律失常的预测因子和最佳切断值.
主要成果:
- 具有QTd≥40毫秒的患者显示SII和AHI显著更高.
- SII (≥625.4) 和AHI (≥22.4) 独立预测增加了QTd和复极化异质性.
- 升高的SII,QTd和TPEI与心室节律失常有关;中度至严重的OSAS与高心室节律失常和心脏突然死亡相关.
结论:
- 升高的SII和AHI是心肌再极化异质性的独立预测因素,在患有OSAS的HF患者中,增加了心律失常风险.
- SII和AHI作为风险分层的可访问生物标志物,特别是在HF患者中具有保存的喷射分数.
- 需要针对炎症和OSAS严重性的有针对性的干预措施来减少心血管事件.
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