醇/二硫化物恒温的预测作用作为在sarcopenic肥胖症中氧化应激参数
Ayse Dikmeer1, Funda Eren2, Salim Neselioglu3
1Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, 06230 Ankara, Türkiye.
Medicina (Kaunas, Lithuania)
|September 27, 2025
概括
患有sarcopenic肥胖症 (SO) 的老年人表现出被破坏的氧化还原平衡,由改变的醇/二硫化物平衡 (TDH) 表明. 二硫化物/原始硫醇比率可能有助于在这个群体中识别SO.
科学领域:
- 老年学是指老年学的学科.
- 生物化学 生物化学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 高龄人群的sarcopenic肥胖症 (SO) 与不良健康结果有关.
- 氧化压力与肥胖和肉症的发展有关.
- 硫化/硫化稳态 (TDH) 和缺血修饰性白蛋白 (IMA) 是氧化应激的标志物.
研究的目的:
- 在肥胖的老年人中调查TDH,IMA和SO之间的关联.
- 在这个人口群体中确定预测SO的氧化应激标志物.
主要方法:
- 一项对132名年龄≥65岁的肥胖个体进行的横截面研究.
- 基于ESPEN/EASO标准的SO诊断 (人体测量,身体组成,肌肉功能).
- 测量血清原生和总硫醇,二硫化物水平和IMA;后勤回归和ROC分析.
主要成果:
- 在15.2%的参与者中发现了SO.
- 患有SO的个体具有明显较低的原生和总醇水平,以及较高的二硫化物/醇比率.
- 硫化物/原始硫醇比率是SO (OR = 5.71) 的独立预测指标,预测准确度中等 (AUC = 0.684).
结论:
- 有SO的肥胖老年人表现出被破坏的氧化还原平衡.
- 二硫化物/原始硫醇比率是识别SO的潜在生物标志物.
- 氧化应激可能在SO中起作用,这表明抗氧化疗法的潜在好处.
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