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立陶宛氧化压力与男性不孕症之间的联系:一项回顾性研究

Eglė Jašinskienė¹, Marija Čaplinskienė¹

¹Department of Biochemistry, Vytautas Magnus University, K. Donelaicio St. 58, 44248 Kaunas, Lithuania.

Medicina (Kaunas, Lithuania)

|September 27, 2025

概括

男性不孕症影响许多夫妇,氧化压力起着关键作用. 这项研究表明,氧化降低潜力 (ORP) 测试可以帮助识别无法解释的男性不孕症病例.

科学领域:

生殖医学生殖医学
安德罗学与人类学
临床诊断临床诊断临床诊断

背景情况:

男性不孕症是一个重要的公共卫生问题,很大一部分病例缺乏明确的原因.
了解男性不孕症的流行病情景对于公共卫生倡议至关重要.
氧化应激越来越被认为是男性生殖健康的一个因素.

研究的目的:

确定立陶宛男性不孕症的流行病学特征.
评估氧化降低潜力 (ORP) 测试使用MiOXSYS系统诊断男性不孕症的临床有用性.
探索ORP评估在重新分类不明原因不育病例中的潜力.

主要方法:

这是一项两阶段的回顾性研究,涉及718名男性进行流行病学分析和261名男性进行ORP测试.
根据世界卫生组织 (WHO) 2010年指南评估的精液参数.
用于确定ORP的诊断精度的接收器操作特征 (ROC) 曲线分析.

主要成果:

在20.1%的夫妻中,男性不孕症是唯一的原因;不明原因不孕症占24.4%.
几乎一半 (48.5%) 的normozoospermic男性显示升高的ORP水平.
ORP测试显示了中度的诊断准确性 (AUC=0.634),并有助于在男性氧化应激不孕症 (MOSI) 框架下重新分类无法解释的病例.

结论:

这项研究提供了关于立陶宛男性不孕症的重要流行病学数据.
氧化降低潜力 (ORP) 测试显示,作为男性不孕不育的补充诊断工具具有前途.
系统的氧化应激评估可以改善无法解释的不孕不育的识别,并个性化治疗策略.

关键词:

立陶宛立陶宛立陶宛这就是MiOXSYSYS.这是ORP ORP.诊断性表现的诊断性表现是什么异形不孕不育不孕症是什么意思男人的不孕不育症.氧化应激是一种氧化应激.

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