白葡萄皮提取,分析概况和生物活动:在循环经济框架内,从实验室到工业规模
Larissa Della Vedova1, Giovanna Baron1, Paolo Morazzoni2
1Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy.
Pharmaceuticals (Basel, Switzerland)
|September 27, 2025
概括
白葡萄皮 (WGS) 是葡萄的副产品,通过绿色提取方法将其转化为有价值的生物活性成分. 这种可持续的方法产生了具有抗炎和抗氧化特性的提取物,展示了循环经济原则.
科学领域:
- 农业工业副产品价值化 农业工业副产品价值化
- 绿色化学的应用绿色化学的应用
- 资源管理中的循环经济原则
背景情况:
- 农业工业副产品的可持续利用对于环境和资源效率至关重要.
- 白葡萄皮 (WGS) 是葡萄生产的蒸残留物,是有价值化合物的潜在来源.
- 废物质标志系统的利用可以减少浪费,创造高价值产品.
研究的目的:
- 为白葡萄皮 (WGS) 开发一个环保的提取工艺.
- 评估和扩大以水为基础的提取方法,用于工业应用.
- 描述生物活性化合物并评估提取物的生物活性.
主要方法:
- 在实验室尺度上对水基和酒提取技术进行比较.
- 优化水性提取工艺的工业扩展.
- 基于LC-HRMS的向代谢学来识别多 (黄,酸).
- 试验室试验评估抗炎和抗氧化活性,包括Nrf2通路激活和细胞毒性.
主要成果:
- 基于水和工业规模的提取物显示出显著的抗炎作用,特别是在胃上皮细胞中.
- 水醇提取物通过Nrf2激活显示出更强的抗氧化活性,但表现出更高的细胞毒性.
- 工业提取物具有双重生物活性,具有适度的Nrf2激活和抗炎性质.
结论:
- 绿色化学和循环经济原则使葡萄废物能够转化为高价值的生物活性成分.
- 开发的以水为基础的提取过程是可扩展和生态可持续的,产生强大的提取物.
- 该研究强调了WGS作为具有双重生物活性的功能成分来源的潜力.
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