凝血杆菌 - - 素共生调节肠道微生物群组成,减轻小鼠中乙醇诱导的酒精性肝病
Zhenzhen Liu1,2, Tong Liu2, Yurong Fan2
1Anti-Infective Agent Creation Engineering Research Centre of Sichuan Province, Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China.
Microorganisms
|September 27, 2025
概括
与巴西凝固素和pectin的协生菌补充剂有效地降低了小鼠的酒精性肝病 (ALD) 严重程度. 这种组合疗法改善了肠道屏障功能,并比单独的成分减少了肝炎.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 滥用酒精和酒精性肝病 (ALD) 是全球重要的健康问题.
- 肠道微生物群失调是ALD发展的关键因素.
- 协生菌,结合益生菌和益生菌,显示在管理ALD通过减少炎症的承诺.
研究的目的:
- 在小鼠模型中研究Bacillus coagulans单独或与pectin (一种益生菌) 结合对乙醇诱导的ALD的治疗作用.
- 评估协生补充剂对肝损伤,炎症,肠道屏障功能和肠道微生物群组成的影响.
主要方法:
- 给患有乙醇诱导的ALD的小鼠注射B.凝血剂,pectin或同生菌 (B.凝血剂 + pectin).
- 评估肝脏组织学,炎症标志物 (TNF-α,IL-1β,MPO),紧结蛋白,粘膜和肠道微生物群组成.
- 测量短链脂肪酸 (SCFA) 的生产.
主要成果:
- 与单独的B.凝血素或pectin相比,同生菌补充剂显著减轻了ALD的严重程度.
- 同生菌治疗减少了肝炎性损伤,脂质积累和促炎性细胞因子水平.
- 协生菌通过上调紧密结蛋白和粘膜,调节肠道微生物群,并增加SCFA生产来增强肠道屏障功能.
结论:
- B.凝血素和pectin的共生配方表明对实验ALD有强大的治疗效果.
- 协生菌通过调节肠道微生物群和增强SCFA生产来缓解炎症并改善ALD中的肠道屏障完整性.
- 这项研究强调了协生菌作为治疗酒精性肝病的有前途战略的潜力.
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