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目前的进展和动物模型在SARS-CoV-2病原和疫苗开发中的应用

Li Wu¹, Yingying Tao², Xing Wu²

¹Department of Biology, College of Life Sciences, China Jiliang University, Hangzhou 310018, China.

|September 27, 2025

概括

本综述总结了用于研究SARS-CoV-2病原和开发疫苗和抗病毒药物的动物模型. 了解这些模型是控制COVID-19传播的关键.

科学领域:

兽医医学兽医医学兽医医学
传染性疾病传染性疾病
病毒学病毒学

背景情况:

由SARS-CoV-2引起的COVID-19是一个重大的全球健康问题.
识别有效的疫苗和治疗方法需要了解病毒病原体.
各种动物物种容易感染SARS-CoV-2,使疾病控制和研究复杂化.

研究的目的:

审查和总结SARS-CoV-2研究的现有和潜在的动物模型.
为特定研究目标选择合适的动物模型提供指导.
为了促进新型疫苗和COVID-19的抗病毒疗法的开发.

主要方法:

涉及动物模型和SARS-CoV-2的研究的文献综述.
收集有关不同物种宿主范围,易感性和疾病表现的数据.
在临床前疫苗和药物评估中分析各种动物模型的实用性.

主要成果:

确定了几个关键的动物模型,包括转基因小鼠,猫,仓鼠,非人类灵长类动物和.
突出了蝙蝠作为水库和鱼作为潜在的中间宿主的作用.
详细介绍了动物模型在研究SARS-CoV-2病原性和评估对策方面的重要性.

结论:

适当的动物模型对于推进COVID-19研究至关重要.
选择合适的动物模型对于成功的临床前研究至关重要.
这一审查有助于明智地选择动物模型,以加快COVID-19预防和控制策略.

关键词:

这就是SARS-CoV-2病毒.动物模型动物模型病原性是一种病原性.在进步方面取得了进展.疫苗,疫苗的使用情况.

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