食纤维补充剂对健康成年人肠道微生物群和肠道功能的影响:随机对照试验
Ryo Inoue1, Kenta Suzuki2, Masachika Takaoka2
1Laboratory of Animal Science, Department of Applied Biological Sciences, Faculty of Agriculture, Setsunan University, Hirakata-shi 573-0101, Osaka, Japan.
食纤维补充剂改善了健康成年人的肠道微生物群和肠道生活质量. 短期高纤维摄入量增加了有益细菌,这表明长时间干预可能会带来更广泛的健康益处.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 人类健康 人类健康 人类健康
背景情况:
- 食纤维对肠道健康起着至关重要的作用.
- 了解纤维对肠道微生物群和生活质量的影响很重要.
研究的目的:
- 评估4周的食纤维补充对肠道微生物群,肠道相关的生活质量,睡眠和皮肤状况的影响.
- 分析特定细菌属和便有机酸的变化.
主要方法:
- 随机,双盲,对105名健康成年人的受控试验.
- 低纤维 (2.2g/天) 与高纤维 (8.2g/天) 的饮食的比较.
- 16S rRNA测序用于肠道微生物群分析,便日记,JPAC-QOL,OSA-MA,皮肤问卷和便有机酸.
主要成果:
- 高纤维组显示了与肠道相关的生活质量 (JPAC-QOL) 的显著改善.
- 在高纤维组中增加了SCFA相关的属 (例如,Anaerostipes,Bifidobacterium,Fusicatenibacter) 的丰度.
- 有益细菌与潜在的肠-大脑/肠-皮肤轴参与之间的正相关性.
结论:
- 短期的纤维补充有效地改善了健康成年人的肠道生活质量和调节了肠道微生物群.
- 微生物转变表明,在持续增加纤维摄入量的情况下,可能会产生更广泛的健康益处.
- 通过更长时间的干预措施进行进一步的研究可能会阐明系统性影响.
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