用于确定阿片类药物和阿片类药物的干矩阵斑点:方法学的进步和应用
Luana M Rosendo1,2, Rita Gonçalves1, Rodrigo Martins1
1RISE-Health, Departamento de Ciências Médicas, Faculdade de Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal.
Molecules (Basel, Switzerland)
|September 27, 2025
概括
干矩阵斑点 (DMS) 技术提供最小侵入性的阿片类药物和阿片类药物的检测. 虽然对临床和法医毒理学有希望,但标准化和恢复问题需要进一步研究才能得到广泛采用.
科学领域:
- 生物分析化学 生物分析化学
- 法医毒理学 法医毒理学
- 分析化学 分析化学
背景情况:
- 干矩阵斑点 (DMS) 技术越来越多地用于生物分析和法医毒理学.
- 这些方法提供了优势,如最小侵入性采样,改善样品稳定性,以及更容易的储存/运输以检测阿片类药物和阿片类药物.
研究的目的:
- 批判性地审查DMS技术在各种生物矩阵中的最新进展和应用.
- 专注于DMS方法的样本准备,提取,仪器仪表和性能评估.
主要方法:
- 关于干矩阵斑点 (DMS) 技术的最新文献的综述.
- 在血液,血,尿液和口腔液中应用的分析.
- 评估样品的准备,提取和分析仪器.
主要成果:
- 建立了干血斑点 (DBS),并扩大了干血,尿液和唾液斑点 (DPS,DUS,DSS) 的使用.
- DMS提供了降低生物危害风险和高通量兼容性,但面临的局限性是样本数量低和回收不一致.
- 替代矩阵正在实现分散和医疗点测试.
结论:
- 在临床和法医环境中,DMS技术对于阿片类药物监测具有多样性.
- 需要进一步优化基质,溶剂兼容性和自动化.
- 程序的标准化对于更广泛的实施至关重要.
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