下一代基于废水的流行病学:绿色自动化用于在废水中检测69种多类药品和个人护理产品,使用LC-MS/MS的96井板固相提取
Bhaskar Karubothula1, Veera Venkataramana Kota1, Dnyaneshwar Shinde1
1RASID Laboratory of Abu Dhabi Quality & Conformity Council (ADQCC) & M42 Environmental Sciences, Abu Dhabi P.O. Box 853, United Arab Emirates.
Molecules (Basel, Switzerland)
|September 27, 2025
概括
本研究引入了一种用于在废水中分析药品和个人护理产品 (PPCPs) 的自动化方法,以加强公共卫生和环境监测. 经过验证的方法为传统检测技术提供了可持续和高效的替代方案.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 环境科学 环境科学
背景情况:
- 在环境样本中检测药品和个人护理产品 (PPCP) 的传统方法是复杂的,资源密集的和不可持续的.
- 需要加强对PPCP的监测,以保护公众健康和环境.
研究的目的:
- 评估一种自动化样品制备方法,使用Biomek i7工作站分析废水中的69种PPCP.
- 开发和验证一种可持续和高效的PPCP检测方法.
主要方法:
- 对UPLC-MS/MS参数进行优化.
- 使用三种类型的固相提取 (SPE) 弹 (MAX,MCX,HLB) 评估提取效率.
- 通过线性,矩阵效应,尖端研究,实验室内部比较和盲人测试来验证自动化方法.
主要成果:
- 混合模式阴离子交换 (MAX) SPE弹显示出最高的提取效率.
- 该方法证明了针对PPCP的特异性,并在69个PPCP中的63个中达到±20%的矩阵效应耐受性.
- 自动化方法符合验证要求,显示可靠性,线性和可接受的恢复率 (80-120%).
结论:
- 使用Biomek i7工作站的自动化样品制备方法可靠,绿色和实用,用于在废水中分析PPCP.
- 这种方法为例行监测提供了可持续和有效的替代方案,有助于公共卫生和环境保护.
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