花果实通过AHR介导的FLG/LOR/IVL表达来增强皮肤屏障功能
Kaile Zong1, Fangni Zhou2, Kewei Xu1
1Skin Health and Cosmetic Development & Evaluation Laboratory, China Pharmaceutical University, Nanjing 211198, China.
Molecules (Basel, Switzerland)
|September 27, 2025
概括
果 (Gardeniae Fructus,简称GF) 通过激活烯碳化合物受体 (AHR) 来增强皮肤屏障功能,从而调节像 filaggrin.grin 这样的关键蛋白质. 这种传统的中医药可以改善皮肤的水分和降低敏感性.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 果园 (Gardeniae Fructus,简称GF) 是一种传统的中医药,以其对皮肤的益处而闻名.
- 通过GF改善表皮屏障功能的精确机制尚未完全理解.
研究的目的:
- 阐明GF皮肤屏障增强背后的机制.
- 为了识别GF中的活性虹膜体及其分子标.
- 为了验证GF在体外,3D模型和人类实验中的有效性.
主要方法:
- UPLC-MS/MS用于虹膜体的表征.
- 在体外测试细胞迁移,损伤和氧化应激.
- 蛋白质组学,分子对接和分子动力学 (MD) 用于目标预测.
- 在HaCaT细胞和3D表皮模型中验证.
- 28天的随机双盲人类疗效研究.
主要成果:
- 在GF中发现了9种虹膜体.
- 在实验室中,GF促进了细胞迁移,并减少了氧化应激.
- 蛋白质组学和计算方法确定了基碳化合物受体 (AHR) 作为一个关键目标.
- GF上调调节了AHR,非拉格林 (FLG),洛里克林 (LOR) 和内林 (IVL) 的表达.
- 人类研究显示皮肤水分增加,TEWL减少,红血减少.
结论:
- GF通过激活AHR增强了皮肤屏障功能,导致屏障蛋白的表达增加.
- GF显示出显著的化品潜力,可以改善敏感皮肤状况.
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