布拉西因诱导H2S信号并改善血管光滑肌细胞功能
Jazmin Fergani1,2, Xiaoli Han3, Zhuping Jin3
1School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada.
Molecules (Basel, Switzerland)
|September 27, 2025
概括
布拉西宁通过促进硫化 (H2S) 生产来保护血管光滑肌肉细胞免受功能障碍,而不是直接释放H2S. 这种机制为心血管疾病治疗提供了潜力.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 布拉西宁是一种植物素,具有抗癌和抗炎性质.
- 硫化 (H2S) 是一种具有已知的心脏保护作用的气体传递物.
- 布拉西宁对H2S信号传递和血管光滑肌细胞 (SMC) 功能的影响尚不清楚.
研究的目的:
- 为了研究布拉西宁对血管素II (Ang II) 诱导的SMC功能障碍的影响.
- 探索潜在的机制,特别是H2S信号的作用.
主要方法:
- 评估了SMC的扩散,迁移和氧化应激.
- 测量了收缩蛋白和炎症基因的表达.
- 研究了H2S的产生和cystathionine gamma-lyase (CSE) 的表达.
- 研究了布拉西宁,C/EBPβ和CSE促进体之间的相互作用.
主要成果:
- 布拉西宁减轻了Ang II诱导的SMC功能障碍,减少了增殖,迁移和氧化应激.
- 布拉西因上调收缩蛋白表达和下调炎症基因表达.
- 布拉西宁通过诱导CSE表达来刺激内源H2S合成,而不会直接释放H2S.
- 发现布拉西宁可以增强对CSE促进体的C/EBPβ结合,从而增加CSE转录.
结论:
- 布拉西宁主要通过通过CSE诱导激活内源H2S信号来保护SMC功能障碍.
- 布拉西宁的机制涉及与C/EBPβ的相互作用,以调节CSE转录.
- 这些发现凸显了布拉西宁作为治疗血管健康和预防心血管疾病的治疗剂的潜力.
更多相关视频
12:00Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
19.8K
06:14Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
Published on: June 11, 2017
8.8K
相关概念视频
Antihypertensive Drugs: Vasodilators
2.0K
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
2.0K
Paracrine Signaling
59.4K
Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
59.4K
Vascular Spasm
3.3K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
3.3K
Nitric Oxide Signaling Pathway
6.2K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.2K
Regulation of Angiogenesis and Blood Supply
3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K
Autoregulation of Blood Flow
7.5K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
7.5K
