与人类乳头瘤病毒感染相关的癌症的全球负担和发病率趋势:基于人口的系统研究
Xiaojun Meng1, Bolin Yang1, Hanlu Yin1
1The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi 214023, China.
Pathogens (Basel, Switzerland)
|September 27, 2025
概括
人类乳头瘤病毒 (HPV) 相关的癌症代表着一个重大的全球健康挑战. 发病率和死亡率因地区,性别和癌症类型而异,宫癌,头癌和门癌需要紧急关注.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 人类乳头瘤病毒 (HPV) 是无遗体和头癌 (HNC) 的主要原因之一.
- 与HPV相关的癌症给全球健康带来了巨大的负担,并存在很大的差异.
- 了解当前的模式和趋势对于有效的干预至关重要.
研究的目的:
- 为HPV相关癌症的发病率和死亡率模式提供最新的全球概述.
- 分析全球各种HPV相关癌症的发病率趋势.
- 检查HPV相关癌症负担与人类发展指数 (HDI) 之间的关联.
主要方法:
- 利用了GLOBOCAN 2022和五大洲的癌症发病率以及摘要数据.
- 计算年龄标准化发病率和死亡率 (ASIR/ASMR),以量化癌症负担.
- 使用斯皮尔曼相关性和Joinpoint回归用于趋势和关联分析.
主要成果:
- 在2022年,全球估计有1,505,394例新的HPV相关癌症病例和755,303例死亡.
- 非洲显示出最高的ASIR和ASMR;低HDI的国家显示出明显高于非常高HDI国家的HDI.
- 宫癌的发病率呈下降趋势,而HNC (女性) 和门癌 (两性) 的发病率呈上升趋势.
结论:
- 与HPV相关的癌症的全球负担和趋势因癌症类型,区域和性别而异.
- 宫癌,头癌和门癌需要全球关注.
- 对高负担癌症的特定国家鉴定对于资源分配和医疗保健改进至关重要.
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