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长生的可持续生产:生物合成和代谢工程的进步

Yang Xue¹, Ruixiang Zhang¹, Tie Li¹

¹Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, South China Agricultural University, Guangzhou 510642, China.

Plants (Basel, Switzerland)

|September 27, 2025

概括

合成生物学提供了一种可持续的替代品,用于生产人参,Panax人参中的活性化合物. 这种方法克服了传统种植的局限性,使这些有价值的药用化合物的高效制造成为可能.

科学领域:

生物技术是生物技术.
合成生物学合成生物学
代谢工程是代谢工程.

背景情况:

帕纳克斯人参中的金色化物具有显著的药理特性.
帕纳克斯人参的传统种植受到长期生长周期,低产量和环境因素的限制.

研究的目的:

审查金氏化物生物合成途径和关键酶.
检查当前合成生物学策略用于生化的生产.
评估生物制造的金赛诺化的药用意义和工业可行性.

主要方法:

详细描述人参化物生物合成途径和调节网络.
合成生物学方法的分析,包括植物细胞/组织/毛发根培养,工程微生物宿主 (Saccharomyces cerevisiae,Escherichia coli) 和无细胞合成.
评估药用价值,市场潜力和工业可扩展性.

主要成果:

在金氏化物合成中确定关键酶 (例如HMG-CoA减少酶,Dammarenediol-II合成酶,UDP-glycosyltransferases).
综述各种合成生物学平台的综述,以实现高效的金氏化物生产.
评估生物制造的经济可行性和可持续性.

结论:

合成生物学和代谢工程为生产人参酸的传统Panax人参种植提供了可持续和高效的替代品.
工程工厂底盘显示了未来类合成的新兴潜力.
先进的生物制造策略解决了农业的局限性,并为可扩展的金氏化物生产提供了一个框架.

关键词:

人参化物生物合成人参酸性enosides 是一种自然产品是自然产品的产品.工厂的底盘和底盘.可持续的生产可持续的生产合成生物学合成生物学

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