美国成年人中的DEET代谢物和听力损失
Rae T Benedict1, Gregory M Zarus1, Franco Scinicariello1
1Office of Innovation and Analytics, Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA 30341, USA.
Toxics
|September 27, 2025
概括
暴露于DEET代谢物M-甲基酸 (DCBA) 的更高水平,与美国成年人高频听力损失 (HFHL) 的几率增加有关. 这项研究揭示了DCBA水平和HFHL严重程度之间的显著关联.
科学领域:
- 环境健康 环境健康
- 听力学 听力学是指听力学.
- 毒理学 毒理学 毒理学
背景情况:
- 听力损失 (HL) 带来了重大挑战.
- N,N-二甲基多胺 (DEET) 是一种广泛使用的驱虫剂和防晒成分.
- 甲基酸 (DCBA) 是DEET的主要尿代谢产物.
研究的目的:
- 调查尿中DCBA水平与美国成年人听力损失之间的潜在关联.
- 探索DEET代谢物暴露与不同类型和严重程度的听力障碍之间的关系.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 的数据.
- 根据听力学值,定义了语音频率听力损失 (SFHL) 和高频率听力损失 (HFHL).
- 将听力损失的严重程度分为正常,轻度和中度或更严重.
- 分析了尿路DCBA四分位数和HFHL之间的关联,使用后勤回归,控制混因素.
主要成果:
- 尿中DCBA度较高与高频听力损失 (HFHL) 的几率增加显著相关.
- 在DCBA暴露四分位数最高的人群中,HFHL的几率显著增加 (aOR = 2.34).
- 观察到一种显著的剂量反应趋势,敏感性分析证实了这种关联在不同HFHL严重程度的强度.
结论:
- 这项研究提供了第一个证据,表明DEET代谢物 (DCBA) 与美国成年人全国代表性样本中的听力损失有关.
- 这些发现表明,高频听力损失可能存在潜在的环境风险因素.
- 需要进一步的研究来阐明这种关联及其临床影响背后的机制.
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