工程大型多孔曼尼托尔-PVA微粒通过喷雾干燥延长药物输送
Karnkamol Trisopon1, Ornanong Suwannapakul Kittipongpatana1, Neungreuthai Chomchoei2
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Pharmaceutics
|September 27, 2025
概括
这项研究使用喷雾干燥开发了大型多孔微粒,用于持续的药物输送. 聚乙醇 (PVA) 改善了颗粒的特性,并控制了二二的释放,显示了可吸入剂型的潜力.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 大型多孔颗粒 (LPPs) 对药物传递有希望,增强分散性和控制释放.
- 它们的多孔结构,大小和形状是优化药物输送性能的关键因素.
研究的目的:
- 通过喷雾干燥开发曼尼托尔,PVA和二甲的持续释放大的多孔微粒 (MPD).
- 研究PVA度对粒子特征和药物释放概况的影响.
主要方法:
- 使用喷雾干燥技术,创建具有不同PVA度 (0-40%) 的MPD.
- 分析了粒子形态,分散性 (卡尔指数),气溶性能和固态特性 (FTIR,XRD,DSC).
- 进行了体外溶解试验,以评估药物释放动力学.
主要成果:
- PVA联合喷雾干燥改善了颗粒形态,产生了具有良好分散性的球形,不粘附的颗粒 (卡尔指数17.56%).
- MPD表现出适合吸入的特征 (直径>5μm,散装密度低<0.1g/cm3).
- PVA改变了曼尼托的多态形式,配方显示了持续的二甲释放,遵循Higuchi模型表明矩阵扩散.
结论:
- 聚乙烯联合喷雾干燥在设计具有理想物理化学性质的大型多孔微粒方面是有效的.
- 开发的MPD显示了量身定制的释放特征和适用于可吸入或可控制释放的剂型.
- 这种方法为先进的药物输送系统开发提供了一个可行的策略.
相关概念视频
01:17Pore Transport and Ion-Pair Transport
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...