基多-PCL双层微球的建模和设计,用于静脉中受控释放的微球
Eduardo A Chacin Ruiz1, Samantha L Carpenter2, Katelyn E Swindle-Reilly3,4,5
1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Pharmaceutics
|September 27, 2025
概括
计算模型可以优化双层微球以持续的静脉内药物递送,通过减少剂量频率来改善慢性视网膜疾病的治疗.
科学领域:
- 生物材料科学 生物材料科学
- 计算建模 计算建模
- 眼科医生 眼科 眼科
背景情况:
- 慢性视网膜疾病需要频繁的局部药物给药,往往导致患者遵守不良.
- 控制释放药物输送系统提供了一个替代方案,以减少静脉内注射剂量频率.
- 开发和商业化这些系统是一个漫长的过程.
研究的目的:
- 为了建模和估计从奇托 - 聚烯酸氨 (PCL) 双层微球中扩散控制的药物释放的参数.
- 优化微球设计以延长药物释放时间.
- 为设计体内药物输送系统提供计算工具.
主要方法:
- 利用有限差异和有限元素方法来解决药物释放的数学模型.
- 用于参数估计的非线性最小平方回归.
- 从奇托-PCL微球中模拟释放牛血清白蛋白和贝瓦齐祖马布.
主要成果:
- 在使用估计参数的各种条件下模拟累积药物释放.
- 优化了设备设计,以提高释放时间超过目标每日治疗速率.
- 研究了聚合物层大小对药物释放动态的影响.
结论:
- 确定了用于增强药物释放的最佳聚合物层大小.
- 开发了用于设计双层微球的计算工具,用于静脉内药物输送.
- 促进了慢性眼睛新血管化的改进治疗方法的设计.
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