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Updated: Jan 16, 2026

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
13:17

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使用PBPK方法间接建模食后肠道淋巴吸收halofantrine:局限性和影响

Malaz Yousef1, Farag E S Mosa1, Khaled H Barakat1

  • 1Faculty of Pharmacy & Pharmaceutical Sciences, Katz Centre for Pharmacy & Health Research, University of Alberta, Edmonton, AB T6G 2E1, Canada.

Pharmaceutics
|September 27, 2025
PubMed
概括

这项研究开发了一种基于生理学的药理动力学 (PBPK) 模型,以模拟脂肪饮食后的口腔淋巴体药物吸收,揭示了养状态下减少的第一通代谢,并强调了直接淋巴体建模的需要.

关键词:
PBPKK PBPK 的意思是什么意思基微粒子是一种基微粒子.哈洛芬特林 (Halofantrine) 是一种类型的粉素.在的中.淋巴细胞吸收的情况

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