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在K18-hACE2转基因小鼠中,SARS-CoV-2Omicron亚型JN.1,KP.2和EG.5.1的致病性

Lila D Patterson^1,2, Amany Elsharkawy¹, Hamid Reza Jahantigh¹

¹Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USA.

|September 27, 2025

概括

与JN.1和KP.2不同的是,SARS-CoV-2 EG.5.1变种在小鼠中引起了严重的疾病和100%的死亡率. EG.5.1还显示了神经侵入,突出显示了变种特定的致病性.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

到2024年1月,SARS-CoV-2 JN.1系在全球占主导地位,与之前的Omicron亚型相比,呈现出显著的抗原差异和免疫逃避.
美国食品和药物管理局建议更新针对JN.1的疫苗配方,因为它具有明显的尖端突变和免疫逃避特性.

研究的目的:

为了比较SARS-CoV-2 JN.1-系 (JN.1,KP.2) 和XBB-系 (EG.5.1) 病毒的病原性.
在转基因小鼠模型中描述病毒感染和宿主-病原体相互作用.

主要方法:

表达人类ACE2的转基因小鼠感染了SARS-CoV-2亚变种JN.1,KP.2和EG.5.1.1.
评估了临床症状,体重减轻,死亡率,病毒复制,肺病理,神经侵袭和免疫细胞群.

主要成果:

JN.1和KP.2感染导致疾病减弱,症状最小,体重没有显著下降.
EG.5.1感染导致严重的疾病,在7天内100%的死亡率,显著的肺病理和具有高脑病毒负担的神经侵入.
EG.5.1感染增加了肺中的CD8+T细胞和树突细胞.

结论:

与JN.1和KP.2相比,SARS-CoV-2 EG.5.1表现出明显而严重的致病性,包括神经侵入性.
这些发现强调了在相关动物模型中对新出现的SARS-CoV-2变种的持续监测和表征的重要性.

关键词:

在表达ACE-2的小鼠中.在 COVID-19 疫情中,在 EG.5.1 中, EG.5.1 在 EG.5.1 中在 JN.1 里面,你会看到 JN.1 .KP.2 这是一个很好的方法.这就是SARS-CoV-2病毒.神经侵袭是一种神经侵入.奥米克朗病毒是什么?病原性病原性病原性有关关注的变种.

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