针对肠道病毒的抗病毒策略:目前的进展和未来的方向
Michelle Felicia Lee1, Seng Kong Tham2, Chit Laa Poh2,3
1Department of Biomedical Sciences, Faculty of Medical and Life Sciences, Sunway University, No.5, Jalan Universiti, Bandar Sunway 46150, Malaysia.
Viruses
|September 27, 2025
概括
对于导致许多疾病的非脊髓灰质炎肠道病毒,目前还没有批准的抗病毒疗法. 本综述探讨了直接作用的抗病毒药物,向宿主的药物以及应对肠道病毒感染的新兴策略.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 药物发现 药物发现 药物发现
背景情况:
- 肠道病毒 (EVs) 是一个多样化的属性,导致人类的重大疾病,如手足口腔疾病和无菌性脑膜炎.
- 尽管它们的流行率和爆发潜力很大,但对于非脊髓灰质炎肠道病毒感染,目前还没有批准任何特定的抗病毒治疗方法.
- 目前的治疗选择有限,需要开发新的抗病毒策略.
研究的目的:
- 提供对目前和新兴的抗病毒策略对肠道病毒的全面审查.
- 检查直接作用的抗病毒药物,宿主向药物和新的治疗方法.
- 确定挑战,并指导未来的研究在肠道病毒抗病毒开发.
主要方法:
- 关于肠道病毒抗病毒疗法的现有研究的文献综述.
- 对直接作用抗病毒药物的分析 (囊酸结合剂,蛋白酶抑制剂,RNA聚合酶抑制剂).
- 探索针对宿主的药物,免疫疗法,RNA干扰,CRISPR和基于的抗病毒药物.
主要成果:
- 目前正在研究多种抗病毒策略,包括直接作用和向宿主的药物.
- 像免疫疗法和基因编辑技术这样的新兴方法显示出有希望.
- 仍然存在重大挑战,包括病毒多样性,耐药性和临床前模型的局限性.
结论:
- 一系列不同的抗病毒策略正在开发中,以对抗肠道病毒感染.
- 解决病毒多样性和耐药性对于有效的治疗开发至关重要.
- 持续的研究对于加速发现急需的肠道病毒疗法至关重要.
相关概念视频
Microorganisms in Medicine and Therapeutics
982
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
982
Viruses with RNA Genomes
824
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
824
Subviral Agents
525
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
525
Size and Structure of Viral Genomes
691
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
691


