在急性乙型肝炎病毒感染后,HBsAg血清转换的预测因素:多中心BUHASDER研究
Ozge Caydasi1, Derya Öztürk Engin1, Ömer Karaşahin2
1Department of Infectious Diseases and Clinical Microbiology, Sancaktepe Education and Research Hospital, Health Sciences University, 34785 Istanbul, Turkey.
Viruses
|September 27, 2025
概括
针对急性乙型肝炎 (AHB) 的抗病毒疗法显示,对HBsAg血清转换的数据有限. 年龄较大独立预测HBsAg血清转化在接受抗病毒治疗的AHB患者中的可能性较低.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 关于抗病毒治疗对急性乙型肝炎 (AHB) 的HBsAg血清转化影响的数据有限.
- 了解影响血清转换的因素对于接受治疗的AHB患者的管理至关重要.
研究的目的:
- 为了评估与HBsAg血清转化相关的因素,在接受抗病毒治疗的AHB成年患者中.
- 在这个患者队列中确定成功的HBsAg血清转换的预测因素.
主要方法:
- 在2018年1月至2023年12月期间对107名AHB成年患者进行了回顾性多中心研究.
- 对70名患者进行了24周的随访分析,比较了具有和没有HBsAg血清转换的患者.
- 使用多变量逻辑回归来确定HBsAg血清转换的独立预测因子.
主要成果:
- 年龄与HBsAg血清转化独立相关 (OR=0.926,95% CI 0.874-0.981,p=0.009).
- 年龄的每一年增加与HBsAg血清转化几率下降0.926倍相关.
- 在66.3%的患者中观察到男性性别;中位数年龄为48岁.
结论:
- 在急性乙型肝炎病毒感染的患者中,年龄是HBsAg血清转化的一个独立预测因素.
- 为AHB接受抗病毒治疗的老年患者可能具有实现HBsAg血清转换的可能性降低.
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