与艾滋病毒感染者生活的ART经验者的神经认知障碍:临床风险因素,注射药物使用和sCD163的分析
Syed Zaryab Ahmed1, Faiq Amin2, Nida Farooqui3
1Department of Biochemistry, Ziauddin University, Karachi 75000, Pakistan.
Viruses
|September 27, 2025
概括
神经认知障碍 (NCI) 在巴基斯坦艾滋病毒感染者 (PLHIV) 中非常普遍. 虽然注射药物使用 (IDU) 和长期感染与NCI有关,但考虑到IDU史,可溶性CD163 (sCD163) 水平与NCI无关.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 艾滋病毒感染者 (PLHIV) 持续的神经元损伤与sCD163.3等免疫激活标志物升高相关.
- 诸如注射药物使用 (IDU) 等危险因素可以独立地损害认知功能,导致神经认知障碍 (NCI).
- 在ART经验丰富的PLHIV中sCD163,IDU和NCI之间的关系尚不清楚.
研究的目的:
- 为了确定巴基斯坦PLHIV中NCI的流行率.
- 调查与NCI相关的风险因素 (包括IDU) 和sCD163水平之间的相互作用.
主要方法:
- 一项涉及150名PLHIV和30名HIV阴性注射毒品者 (PWID) 的横截面研究.
- 使用国际艾滋病毒痴呆症量表 (IHDS) 的NCI查.
- 针对sCD163水平的ELISA和物流回归分析以确定NCI预测因素.
主要成果:
- 在PLHIV中观察到高NCI患病率 (83.33%),记忆回忆受到显著影响.
- 长期的艾滋病毒感染 (OR:2.99) 和IDU史与NCI有显著的关联.
- 在具有NCI的PLHIV中,sCD163水平较低,但在调整以IDU史后,这种关联消失了 (OR:0.998).
结论:
- 在巴基斯坦PLHIV中存在NCI的高患病率.
- 在调整以IDU史时,在sCD163水平和NCI之间没有发现显著的关联.
- 药物注射和长期感染是与PLHIV中NCI相关的关键因素.
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