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在西西里的一个中心进行HCV查:描述性队列概况

Maria G Minissale¹, Salvatore Petta², Fabio Cartabellotta¹

¹Internal Medicine Unit, Buccheri La Ferla Fatebenefratelli Hospital, Via Messina Marine 197, 90123 Palermo, Italy.

|September 27, 2025

概括

在西西里岛的查发现3%的抗HCV阳性率,随着年龄的增长而增加. 在16.4%的阳性病例中发现了活跃感染,突出显示了有针对性的查计划的需要.

科学领域:

肝病学肝病学是一种肝病学.
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

意大利的C型肝炎病毒 (HCV) 感染率显示出地理差异,并受到直接作用抗病毒疗法 (DAA) 的影响.
之前关于HCV流行病的流行病学研究已经过时,需要最新的数据.
该研究解决了在西西里岛更新HCV流行数据的需求,考虑到DAA的影响.

研究的目的:

评估西西里一家医院的住院和门诊患者中C型肝炎病毒 (HCV) 感染的流行率.
评估查人口中活跃HCV感染的比例.
为了确定在患有活跃HCV感染的患者中服用DAA治疗的情况.

主要方法:

一项基于医院的查研究于2019年11月至2022年3月在西西里巴勒莫的Buccheri La Ferla医院进行.
连续的住院患者和门诊患者使用血清检测进行了抗HCV抗体查.
对抗HCV阳性个体进行了HCV-RNA测试,以确定活跃感染状态.

主要成果:

在15550名患者中,469人 (3%) 呈阳性抗HCV抗体检测结果.
抗HCV阳性随着年龄的增长而增加,从40岁以下的0.4%到80岁以上的6.4%不等.
活跃的HCV感染 (HCV-RNA阳性) 在16.4%的抗HCV阳性患者中得到证实,其中44.1%接受DAA治疗.

结论:

肝炎查计划对于识别有肝病进展和传播风险的个体是有价值的.
实施实验室策略,如HCV反射检测和专门的关联护理计划,可以提高查效率.
专注于高风险人群可以进一步优化HCV查计划的结果.

关键词:

在HCV病毒感染的过程中,查检查查检查查检查查检查

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