中国草药化合物微生态剂 (C-MEA) 通过微生物群-肠-卵巢轴改善子产的卵子生产性能
Yanfeng Lu1, Lei Zhang1, Rui Zhu1,2
1School of Animal Science and Technology, Jiangsu Agri-Animal Husbandry Vocational College, Taizhou 225300, China.
Veterinary sciences
|September 27, 2025
概括
中国草药化合物微生态剂 (C-MEA) 通过增强卵巢毛囊发育和改变肠道微生物群,改善了子的卵子产量. 这突出了微生物群-肠-卵巢轴的生殖性能.
科学领域:
- 动物科学动物科学
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 中的产卵经常面临生殖表现和肠道健康方面的挑战.
- 中国草药化合物微生态剂 (C-MEA) 是一种潜在的治疗剂.
- 了解C-MEA对微生物群-肠-卵巢轴的影响对于提高子生产率至关重要.
研究的目的:
- 研究C-MEA对子产卵和卵巢发育在中的产卵的影响.
- 分析C-MEA对卵巢转录组和卵巢微生物群的影响.
- 探索肠道微生物群和宿主基因表达之间的关系,在生殖性能的背景下.
主要方法:
- 一项为期30天的养试验,涉及108只黑色莫斯科,分为三个组 (对照组,8g/kg C-MEA,16g/kg C-MEA).
- 评估卵子生产,卵巢卵泡发育,卵巢转录组 (RNA-Seq) 和乳头微生物群 (16S rRNA基因测序).
- 生物信息分析用于识别关键路径,基因和微生物种类,并探索它们之间的相关性.
主要成果:
- 与对照组和高剂量组相比,8g/kg的C-MEA剂量显著增加了卵子生产率,并促进了卵巢卵泡的发育.
- RNA-Seq揭示了神经活性联体受体相互作用和卵巢中PPAR信号传递等途径的显著丰富.
- 在C-MEA治疗组中,16SrRNA测序显示了微生物多样性的增加和诸如*Sphaerochaeta*和*UCG-004*等属的丰度变化,其中*Sphaerochaeta*和关键卵巢基因之间有着显著的相关性.
结论:
- 补充C-MEA,特别是8g/kg,积极调节中的产卵的卵子性能和卵巢卵泡发育.
- 这项研究表明微生物群-肠-卵巢轴在调节生殖功能方面的重要作用.
- 这些发现为利用C-MEA提高产卵的肠道健康和生殖效率提供了基础.
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