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饮食总抗氧化能力与伊朗人克洛托基因表达之间的关联

Zahra Rahimi¹, Monirsadat Mirhoseini¹, Ghazaleh Eslamian²

¹Department of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Genes & nutrition

|September 27, 2025

概括

饮食中较高的抗氧化剂摄入量与健康成年人的Klotho基因表达增加有关. 这表明抗氧化剂,特别是,可能通过基因调节在调节衰老方面发挥作用.

科学领域:

老年学和分子生物学
营养科学营养科学
基因表达分析基因表达分析

背景情况:

氧化应激是细胞衰老的一个关键因素.
饮食中的抗氧化剂可能会通过克洛托基因影响衰老.
研究了成年人饮食中抗氧化能力与Klotho基因表达之间的联系.

研究的目的:

为了检查饮食总抗氧化能力 (DTAC) 和Klotho基因表达之间的关联.
探索饮食中抗氧化剂在调节与衰老相关的基因表达中的作用.
为调节衰老的饮食策略提供证据.

主要方法:

对50名健康的伊朗成年人 (18-40岁) 的横截面研究.
饮食总抗氧化能力 (DTAC) 是根据食物频率调查问卷计算的.
用RT-PCR评估PBMC中的克洛托mRNA水平;用于分析的线性回归.

主要成果:

更高的DTAC与更高的Klotho基因表达 (较低的ΔCt值) 有显著的关联.
经过调整以考虑混因素后,这种关联仍然很重要.
是唯一一个单独的抗氧化剂,与Klotho表达有显著的独立反向关系.

结论:

饮食中增加的抗氧化剂摄入量,特别是,与Klotho基因表达升高有关.
这表明抗氧化剂丰富的饮食如何影响衰老的潜在机制.
新的人类证据将DTAC与Klotho表达联系起来,支持进一步研究对衰老的饮食干预.

关键词:

抗氧化剂是一种抗氧化剂.饮食饮食饮食饮食基因表达调节基因表达调节人类人类人类人类人类克洛托蛋白是一种克洛托蛋白质.氧化应激是一种氧化应激.

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