升高的CircYthdc2表达与攻击性特征和肝细胞癌中不良的无进展生存率相关
Yin Gong1, Xiangcheng Li1, Mingming Wang2
1Department of Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
BMC gastroenterology
|September 27, 2025
概括
循环RNA circYTHDC2显示为肝肝细胞癌 (LIHC) 的生物标志物具有前途. 高水平的cirCYTHDC2表明了侵袭性疾病和低生存率,有助于临床管理.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 肝肝细胞癌 (LIHC) 是癌症死亡的主要原因.
- 目前的LIHC诊断方法在灵敏度和特异性方面存在局限性.
- 循环RNAs (circRNAs) 正在成为稳定,组织特异的生物标志物.
研究的目的:
- 研究circYTHDC2作为LIHC的潜在生物标志物的作用.
- 评估circYTHDC2在LIHC患者的诊断准确性和预后价值.
主要方法:
- 使用UALCAN数据库对YTHDC2甲基化和表达的生物信息分析.
- 定量实时PCR (qRT-PCR) 用于测量患者组织,血清和细胞系中的circYTHDC2表达.
- 接收器操作特征 (ROC) 分析用于诊断准确性和稳定性测试.
主要成果:
- 与对照组相比,LIHC组织和血清中circYTHDC2的调节显著上升.
- circYTHDC2表现出高的诊断准确性 (组织AUC=0.846,血清0.788) 和稳定性.
- 升高的circYTHDC2水平与晚期瘤阶段,大小,转移和门入侵相关,并且与较短的无进展生存时间有关.
结论:
- circYTHDC2是LIHC的稳定和临床相关的生物标志物.
- circYTHDC2具有显著的诊断准确性和预后价值.
- circYTHDC2可能有助于LIHC患者的临床管理,因为它与侵略性特征和存活率有关.
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