与肠球菌相关的医疗保健相关的腹腔炎和脑膜炎:从临床实践中获得的多中心回顾性病例系列
Yuyang Qiu1, Yi Ye2, Qiujun Yang3
1Department of Emergency, the Second People's Hospital of Guiyang, No.547, Jinyang South Road, Guiyang, Guanshanhu , China.
BMC neurology
|September 27, 2025
概括
由Enterococci引起的与医疗保健相关的腹腔炎和脑膜炎 (HCAVM) 是严重的. 这项研究详细介绍了Enterococcus耐药性模式和结果,为这些困难的感染提供了抗菌选择的信息.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 临床医学 临床医学
背景情况:
- 医疗保健相关的腹腔炎和脑膜炎 (HCAVM) 呈现出显著的发病率和死亡率.
- 与肠球菌相关的HCAVM研究不足,特别是在药物耐药性和结果方面.
- 阴性细菌是常见的病因,但Enterococci也是重要的病原体.
研究的目的:
- 调查与菌相关的HCAVM中的细菌耐药性模式.
- 分析与肠球菌相关的HCAVM的抗微生物治疗策略和临床结果.
- 提供数据,以便在HCAVM中进行知情的抗微生物剂选择.
主要方法:
- 多中心回顾案例系列.
- 分析了来自三个三级医院的94种导致HCAVM的Enterococci菌株.
- 评估细菌耐药性,治疗方案和患者的结果.
主要成果:
- 鉴定出了Enterococcus faecalis (58个菌株) 和Enterococcus faecium (34个菌株) 的种类.
- 旺科米辛的耐药性为7.4% (所有在E. faecium);线索利德的耐药性为1.1%.
- E. faecium对10种药物表现出比E. faecalis更高的耐药性;4.3%的治疗是无效的,8.5%的治疗结果不佳.
结论:
- 在E. faecalis和E. faecium之间存在明显的万科米辛和线索利德抗药率.
- 阐明了与肠球菌相关的HCAVM的临床流行病学特征.
- 这些发现为选择抗微生物药物用于抗Enterococci相关的HCAVM提供了关键指导.
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