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母亲口腔微生物群对小型易受伤害的新生儿风险的影响:一个嵌套病例控制研究

Xingying Li¹, Qiuli Xiao¹, Xu Xiong²

¹School of Public Health, NHC Key Lab of Health Technology Assessment, Fudan University, Mailbox 175, 138 Yixueyuan Road, Shanghai, 200032, China.

BMC oral health

|September 27, 2025

概括

孕产妇口腔微生物群的多样性在分娩小脆弱新生儿 (SVN) 的妇女中较低. 在怀孕前和怀孕期间,Granulicatella和Streptococcus的特定细菌被丰富,这可能会影响婴儿的健康.

科学领域:

微生物组研究的研究.
孕产妇和儿童的健康
新生儿结局的结果.

背景情况:

小脆弱新生儿 (SVN) 在全球新生儿死亡率上有着显著的贡献.
孕产妇牙周病与早产 (PTB) 和低出生体重 (LBW) 有关,但潜在的机制尚不清楚.
了解母体口腔微生物群在SVN发育中的作用至关重要.

研究的目的:

调查母体口腔微生物群组成与SVN的分娩之间的关联.
在怀孕前期和怀孕后期分析口腔微生物群概况.
确定与新生儿不良结果相关的特定微生物特征.

主要方法:

一个嵌套病例控制研究,涉及240名妇女 (48例分娩SVN,192例分娩正常新生儿).
在怀孕前期和怀孕后期采集非刺激的唾液样本.
用于口腔微生物群分析的16S rRNA基因测序.

主要成果:

在SVN分娩的妇女在怀孕前表现出口腔微生物群丰富度降低,并在怀孕后期表现出较低的多样性 (香农,辛普森指数).
Genera Granulicatella和Streptococcus在怀孕前和怀孕期间从SVN分娩的妇女的唾液中得到了显著的丰富.
丰富的属与参与乳糖和银河糖降解的代谢途径相关,在PTB和SGA亚组中普遍存在.

结论:

母亲口腔微生物群的多样性在分娩SVN的女性中明显较低.
在怀孕前和怀孕期间,母体唾液中Granulicatella和Streptococcus的丰富与SVN分娩有关.
这些发现表明,母亲口腔健康和新生儿不良结果之间存在潜在的微生物联系.

关键词:

16S rRNA 是一个16S rRNA.嵌套病例控制研究研究.口腔的微生物群.皮克鲁斯t2t2t2t2t 小的易受伤害的新生儿.

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