改变治疗方案后12个月的B/F/TAF和dolutegravir治疗方案的临床结果:一个观察性队列研究
Paul E Sax1, Janna Radtchenko2, Megan Dunbar3
1Brigham and Women's Hospital, Boston, MA, USA.
AIDS research and therapy
|September 27, 2025
概括
基于比克特格拉维尔/emtricitabine/tenofovir alafenamide (B/F/TAF) 和 dolutegravir (DTG) 的疗法在艾滋病毒感染者 (PWH) 中显示出高水平的病毒抑制. 这些安全和简单的选择支持抑制PWH的治疗成功.
科学领域:
- 病毒学和传染病学.
- 药理学和治疗学 药理学和治疗学
- 临床医学 临床医学
背景情况:
- 针对病毒学上被抑制的HIV感染者 (PWH) 的回顾性观察性研究.
- 评估切换到基于比克特格拉维尔/埃姆特里西塔宾/特诺福维尔阿拉芬胺 (B/F/TAF) 或杜洛特格拉维尔 (DTG) 的疗法.
- 单片 (STR) 和多片 (MTR) 配方的比较.
研究的目的:
- 评估PWH转换抗逆转录病毒疗法的临床使用和治疗结果.
- 为了比较B/F/TAF和基于DTG的疗法 (STR和MTR) 之间的结果.
- 为了确定与转换后病毒抑制相关的因素.
主要方法:
- 对经过治疗的PWH (病毒载量<200副本/毫升) 的电子医疗和分发记录的分析.
- 在转换后12个月的B/F/TAF,DTG STR和DTG MTR组的比较.
- 多变量后勤回归用于识别病毒抑制的预测因素,控制人口统计和坚持 (PDC ≥80%).
主要成果:
- 在所有组中观察到高的病毒抑制率 (B/F/TAF:97%,DTG STR:98%,DTG MTR:98%).
- 与DTG MTR (67%) 和B/F/TAF (69%) 相比,DTG STR组 (76%) 的坚持率更高 (PDC ≥80%).
- 白人种族,坚持 (PDC ≥80%) 和较高的基线CD4计数 (≥200细胞/毫米3) 与抑制有关.
结论:
- 基于B/F/TAF和DTG的疗法在PWH中实现了高病毒抑制.
- 这些疗法被认为是病毒抑制PWH的有效切换选择.
- B/F/TAF在坚持挑战方面表现出宽恕,保持病毒学结果.
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